Bhusal Ram Prasad, Bashiri Ghader, Kwai Brooke X C, Sperry Jonathan, Leung Ivanhoe K H
School of Chemical Sciences, The University of Auckland, Private Bag 92019, Victoria Street West, Auckland 1142, New Zealand.
School of Biological Sciences, The University of Auckland, Private Bag 92019, Victoria Street West, Auckland 1142, New Zealand.
Drug Discov Today. 2017 Jul;22(7):1008-1016. doi: 10.1016/j.drudis.2017.04.012. Epub 2017 Apr 27.
Tuberculosis (TB) is an infectious disease caused by Mycobacterium tuberculosis that can remain dormant for many years before becoming active. One way to control and eliminate TB is the identification and treatment of latent TB, preventing infected individuals from developing active TB and thus eliminating the subsequent spread of the disease. Isocitrate lyase (ICL) is involved in the mycobacterial glyoxylate and methylisocitrate cycles. ICL is important for the growth and survival of M. tuberculosis during latent infection. ICL is not present in humans and is therefore a potential therapeutic target for the development of anti-TB agents. Here, we explore the evidence linking ICL to persistent survival of M. tuberculosis. The structure, mechanism and inhibition of the enzyme is also discussed.
结核病（TB）是由结核分枝杆菌引起的一种传染病，它可以在活跃之前潜伏多年。控制和消除结核病的一种方法是识别和治疗潜伏性结核病，防止受感染个体发展为活动性结核病，从而消除疾病的后续传播。异柠檬酸裂解酶（ICL）参与分枝杆菌的乙醛酸和甲基异柠檬酸循环。ICL对于结核分枝杆菌在潜伏感染期间的生长和存活很重要。ICL在人类中不存在，因此是开发抗结核药物的潜在治疗靶点。在这里，我们探讨了将ICL与结核分枝杆菌持续存活联系起来的证据。还讨论了该酶的结构、机制和抑制作用。
