注意缺陷多动障碍成人的受伤风险：一项在台湾进行的全国性、匹配队列、基于人群的研究。
The risk of injury in adults with attention-deficit hyperactivity disorder: A nationwide, matched-cohort, population-based study in Taiwan.
作者信息
Chien Wu-Chien, Chung Chi-Hsiang, Lin Fu-Huang, Yeh Chin-Bin, Huang San-Yuan, Lu Ru-Band, Chang Hsin-An, Kao Yu-Chen, Chiang Wei-Shan, Chou Yu-Ching, Tsao Chang-Huei, Wu Yung-Fu, Tzeng Nian-Sheng
机构信息
Department of Medical Research, Tri-Service General Hospital, National Defense Medical Center, Taipei, Taiwan, ROC; School of Public Health, National Defense Medical Center, Taipei, Taiwan, ROC.
Department of Medical Research, Tri-Service General Hospital, National Defense Medical Center, Taipei, Taiwan, ROC; School of Public Health, National Defense Medical Center, Taipei, Taiwan, ROC; Taiwanese Injury Prevention and Safety Promotion Association, Taipei, Taiwan, ROC.
出版信息
Res Dev Disabil. 2017 Jun;65:57-73. doi: 10.1016/j.ridd.2017.04.011. Epub 2017 May 2.
BACKGROUND
Few studies have investigated the risk of injuries associated with adults with attention-deficit hyperactivity disorder (ADHD), even though several studies have suggested a higher risk of injury in children and adolescents with ADHD.
AIMS
To investigate the risk of injury in adults with ADHD.
METHODS AND PROCEDURES
We included 665 adults with ADHD from January 1, to December 31, 2000, and 1995 sex-, age- and index day-matched controls without ADHD from the Longitudinal Health Insurance Database (LHID) subset of the National Health Insurance Research Database in Taiwan. The Cox proportional hazard models were used to analyze the associations between the relevant demographics, and the psychiatric comorbidities and the risk of injury.
OUTCOMES AND RESULTS
The patients with ADHD had a 143% increased risk of overall injuries than the controls after considering all the confounding factors. In addition, the use of methylphenidate was associated with a 22.6% decrease in the risk of injuries in the patients with ADHD.
CONCLUSIONS AND IMPLICATIONS
Our findings strongly support that adults with ADHD are at an increased risk of injury, and imply that methylphenidate therapy may attenuate this risk.
背景
尽管多项研究表明患有注意力缺陷多动障碍（ADHD）的儿童和青少年受伤风险较高，但很少有研究调查患有ADHD的成年人的受伤风险。
目的
调查患有ADHD的成年人的受伤风险。
方法与步骤
我们纳入了2000年1月1日至12月31日期间665名患有ADHD的成年人，以及来自台湾国民健康保险研究数据库纵向健康保险数据库（LHID）子集中1995名年龄、性别和索引日匹配的无ADHD对照者。采用Cox比例风险模型分析相关人口统计学特征、精神疾病共病与受伤风险之间的关联。
结果
在考虑所有混杂因素后，患有ADHD的患者总体受伤风险比对照组高143%。此外，使用哌甲酯与患有ADHD的患者受伤风险降低22.6%相关。
结论与启示
我们的研究结果有力地支持了患有ADHD的成年人受伤风险增加，并表明哌甲酯治疗可能会降低这种风险。
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