Seo U Min, Nguyen Duc Hung, Zhao Bing Tian, Min Byung Sun, Woo Mi Hee
College of Pharmacy, Catholic University of Daegu, Gyeongsan 38430, Republic of Korea.
College of Pharmacy, Catholic University of Daegu, Gyeongsan 38430, Republic of Korea; Phutho College of Pharmacy, Viettri City, Phutho Province 290000, Viet Nam.
Carbohydr Res. 2017 Jun 5;445:75-79. doi: 10.1016/j.carres.2017.04.014. Epub 2017 Apr 15.
Two new flavanonol glucoside isomers, (2R,3S)-dihydrokaempferol 3-O-β-D-glucoside (1) and (2S,3R)-dihydrokaempferol 3-O-β-D-glucoside (2), were isolated from the aerial parts of Agrimonia pilosa Ledeb., along with eight known flavanonol glucosides (3-10). Their structures were determined on the basis of spectroscopic analysis. In addition, these compounds were evaluated to determine their acetylcholinesterase inhibitory activities. The results indicated that these compounds have moderate inhibitory effects, with IC values ranging from 76.59 ± 1.16 to 97.53 ± 1.64 μM, except compounds 1 and 4 were inactive.
从龙牙草地上部分分离得到两种新的黄烷醇苷异构体，即(2R,3S)-二氢山奈酚3-O-β-D-葡萄糖苷（1）和(2S,3R)-二氢山奈酚3-O-β-D-葡萄糖苷（2），以及8种已知的黄烷醇苷（3 - 10）。通过光谱分析确定了它们的结构。此外，对这些化合物进行了评估以测定其乙酰胆碱酯酶抑制活性。结果表明，这些化合物具有中等抑制作用，IC值范围为76.59±1.16至97.53±1.64μM，除化合物1和4无活性外。
