Kolahdouz Mohammadi Roya, Arablou Tahereh
Department of Nutrition, School of Public Health, Iran University of Medical Sciences, Hemmat Highway, 1449614535, Tehran, Iran.
Department of Nutrition, School of Public Health, Iran University of Medical Sciences, Hemmat Highway, 1449614535, Tehran, Iran.
Biomed Pharmacother. 2017 Jul;91:220-228. doi: 10.1016/j.biopha.2017.04.078. Epub 2017 Apr 28.
Endometriosis is characterized by the existence of endometrial tissue and stroma exterior to the uterus. Despite the high prevalence, the etiology of endometriosis remains elusive. The search for the most promising compounds for treatment of endometriosis has led to the identification of resveratrol. Resveratrol, a plant-derived polyphenolic phytoalexin, demonstrates broad-spectrum health beneficial effects, including anti-proliferative, anti-inflammatory, antineoplastic and antioxidant. Because of these properties and its wide distribution in plants, resveratrol is proposed as a great potential to treat endometriosis. In animal models of endometriosis, resveratrol supplementation has displayed beneficial results as it decreased the number and volume of endometrial implants, suppressed proliferation, vascularization, inflammation, cell survival and increased apoptosis. On the other hand, resveratrol treatment in-vitro studies, reduced invasiveness of endometriotic stromal cells (ESCs) and suppressed their inflammatory responses. In this review, we will summarize the recent studies in in-vitro and animal studies on resveratrol and endometriosis.
子宫内膜异位症的特征是子宫外存在子宫内膜组织和间质。尽管发病率很高，但子宫内膜异位症的病因仍然不明。对治疗子宫内膜异位症最有前景的化合物的研究已导致白藜芦醇的发现。白藜芦醇是一种植物来源的多酚类植保素，具有广泛的有益健康作用，包括抗增殖、抗炎、抗肿瘤和抗氧化作用。由于这些特性及其在植物中的广泛分布，白藜芦醇被认为具有治疗子宫内膜异位症的巨大潜力。在子宫内膜异位症动物模型中，补充白藜芦醇显示出有益效果，因为它减少了子宫内膜植入物的数量和体积，抑制了增殖、血管生成、炎症、细胞存活并增加了细胞凋亡。另一方面，白藜芦醇的体外研究表明，它降低了子宫内膜间质细胞（ESC）的侵袭性并抑制了它们的炎症反应。在这篇综述中，我们将总结最近关于白藜芦醇和子宫内膜异位症的体外和动物研究。
