Bakaletz L O, Hoepf T M, DeMaria T F, Lim D J
Department of Otolaryngology, Ohio State University College of Medicine, Columbus.
Am J Otolaryngol. 1988 May-Jun;9(3):127-34. doi: 10.1016/s0196-0709(88)80018-8.
The adherence of Hemophilus influenzae (type b and nontypable) to ciliated chinchilla respiratory epithelium was investigated using a whole organ perfusion technique. Nontypable H influenzae (NTHi) were shown to be more adherent than type b to these organized and differentiated tracheal organ cultures. Bacteria were found adhering to ciliated cells. Antecedent influenza A virus infection had no effect on adherence of NTHi for at least 48 hours. However, 72 hours after exposure to the virus, infected tissues demonstrated significantly fewer adherent bacteria than did controls. To summarize, influenza A virus infection was not found to augment the initiation of NTHi adherence to ciliated respiratory epithelium in this model.
使用全器官灌注技术研究了流感嗜血杆菌（b型和不可分型）对有纤毛的栗鼠呼吸道上皮的黏附性。结果显示，不可分型流感嗜血杆菌（NTHi）比b型流感嗜血杆菌对这些有组织且分化的气管器官培养物的黏附性更强。发现细菌黏附于有纤毛的细胞。甲型流感病毒感染至少48小时内对NTHi的黏附性没有影响。然而，在接触病毒72小时后，受感染组织中的黏附细菌明显少于对照组。总之，在该模型中未发现甲型流感病毒感染会增强NTHi对有纤毛呼吸道上皮的初始黏附。
