Kanno Nobuyuki, Suzuki Tomohiro
Division of Veterinary Cardiovascular Medicine and Surgery, Laboratory of Veterinary Medical Therapeutics, Department of Veterinary Medicine, College of Bioresource Sciences, Nihon University, 1866 Kameino, Fujisawa-shi, Kanagawa 252-0880, Japan.
Ikime Animal Hospital, 3036-4 Ukita, Ooaza, Miyazakishi, Miyazaki 880-2104, Japan.
J Vet Med Sci. 2017 Jun 16;79(6):1031-1034. doi: 10.1292/jvms.17-0018. Epub 2017 May 1.
Sick sinus syndrome (SSS) is a type of bradyarrhythmia that can lead to syncope. Cilostazol has been reported to be an effective treatment for human patients with SSS and other bradyarrhythmias. This report describes the successful long-term treatment with cilostazol in a dog with SSS. A nine-year old intact male Miniature Schnauzer presented with a history of syncopal episodes and unsteady gait. After cilostazol treatment, the total heart rate (HR), mean HR, and frequency of premature ventricular contractions (PVCs) increased, while the maximum HR and maximum pause time decreased. Additionally, the number of syncopal episodes decreased. The dog died suddenly, 1,418 days after the start of cilostazol treatment. Cilostazol may be a useful therapeutic agent in canines with SSS.
病态窦房结综合征（SSS）是一种可导致晕厥的缓慢性心律失常。据报道，西洛他唑对患有SSS和其他缓慢性心律失常的人类患者是一种有效的治疗方法。本报告描述了用西洛他唑对一只患有SSS的犬进行长期成功治疗的情况。一只9岁未绝育的雄性迷你雪纳瑞出现晕厥发作和步态不稳的病史。西洛他唑治疗后，总心率（HR）、平均心率和室性早搏（PVC）频率增加，而最大心率和最大停顿时间减少。此外，晕厥发作次数减少。这只犬在开始西洛他唑治疗1418天后突然死亡。西洛他唑可能是患有SSS的犬的一种有用治疗药物。
