Iwasa Naoki, Nishii Naohito, Takashima Satoshi, Kobatake Yui, Nomura Saki, Iwasa Kazuko, Iwasa Tatsuo, Suzuki Tomomi, Machida Noboru, Kitagawa Hitoshi
Hashima Animal Hospital, Gifu, Japan.
Laboratory of Veterinary Internal Medicine, Faculty of Applied Biological Sciences, Gifu University, Gifu, Japan.
JFMS Open Rep. 2019 Oct 20;5(2):2055116919878913. doi: 10.1177/2055116919878913. eCollection 2019 Jul-Dec.
A 12-year-old neutered female domestic shorthair cat was admitted for syncope. Clinical signs and electrocardiography revealed high-grade atrioventricular (AV) block. Treatment with cilostazol ameliorated the clinical signs and arrhythmia. However, the high-grade AV block recurred on several occasions. After 640 days, the cat presented again with clinical deterioration owing to reoccurrence of the arrhythmia and it died 11 days later. Histopathological examination revealed a loss of conduction cells within the His bundle.
To our knowledge, this is the first report of high-grade AV block treated with cilostazol in a cat. Treatment with cilostazol prolonged survival for 650 days without pacemaker implantation. Histological findings suggested that the AV block was related to fibrosis of the impulse conduction system.
一只12岁已绝育的雌性家养短毛猫因晕厥入院。临床症状和心电图显示高度房室传导阻滞。西洛他唑治疗改善了临床症状和心律失常。然而，高度房室传导阻滞多次复发。640天后，这只猫因心律失常复发导致临床病情恶化，11天后死亡。组织病理学检查显示希氏束内传导细胞缺失。
据我们所知，这是首例用西洛他唑治疗猫高度房室传导阻滞的报告。西洛他唑治疗使猫在未植入起搏器的情况下存活了650天。组织学检查结果提示房室传导阻滞与冲动传导系统的纤维化有关。
