氯胺酮-地西泮、氯胺酮-赛拉嗪和氯胺酮-乙酰丙嗪在里海池龟中的麻醉效果()。（注：括号内原文内容缺失）

Anesthetic efficacy of ketamine-diazepam, ketamine-xylazine, and ketamine-acepromazine in Caspian Pond turtles ().

作者信息

Adel Milad, Sadegh Amin Bigham, Arizza Vincenzo, Abbasi Hossein, Inguglia Luigi, Saravi Hasan Nasrollahzadeh

机构信息

Department of Aquatic Animal Health and Diseases, Iranian Fisheries Science Research Institute, Agricultural Research Education and Extension Organization, Tehran, Iran.

Department of Clinical Sciences, Faculty of Veterinary Medicine, Shahrekord University, Shahrekord, Iran.

出版信息

Indian J Pharmacol. 2017 Jan-Feb;49(1):93-97. doi: 10.4103/0253-7613.201023.

DOI:10.4103/0253-7613.201023

PMID:28458430

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5351246/

Abstract

OBJECTIVES

The objective of this study was to assess the efficacy of different anesthetic drug combinations on the Caspian Pond turtles ().

SUBJECTS AND METHODS

Three groups of the Caspian Pond turtles ( = 6) were anesthetized with three different drug combinations. Initially, a pilot study was conducted to determine the best drug doses for the anesthetization of the turtles, and according to these results, ketamine-diazepam (120 mg/kg ketamine hydrochloride [5%] and 2 mg/kg diazepam [5%]), ketamine-acepromazine (120 mg/kg ketamine hydrochloride [5%] and 1 mg/kg acepromazine [1%]), and ketamine-xylazine (120 mg/kg ketamine hydrochloride [5%] and 1 mg/kg xylazine [2%]) were injected intramuscularly. The onset times of anesthetization and the recovery time were measured. Statistical analysis of the data was performed using one-way analysis of variance followed by -tests, and < 0.05 was considered statistically significant.

RESULTS

There were statistically significant differences in the mean of the onset times of anesthesia and recovery time among the three drug combinations depending on the treatment used. The onset of anesthesia of the animals treated with the ketamine-diazepam combination was 60% and 42% shorter, for male and female turtles, respectively, compared to that obtained with the ketamine-acepromazine combination and 64% (male turtles) and 50% (female turtles) shorter than that obtained with the ketamine-xylazine combination. Further, the recovery time, in male turtles, was 17% shorter in animals treated with the first drug combination than those treated with the ketamine-acepromazine combination and 37% shorter than those treated with the ketamine-xylazine combination. The recovery time, in female turtles, did not seem to be significantly different among treatments.

CONCLUSIONS

The study showed that the ketamine-diazepam drug combination is the anesthetic combination with the fastest onset time and shortest recovery time.

摘要

目的

本研究的目的是评估不同麻醉药物组合对里海池龟的麻醉效果。

对象与方法

三组里海池龟（每组n = 6）分别用三种不同的药物组合进行麻醉。最初，进行了一项初步研究以确定龟麻醉的最佳药物剂量，并根据这些结果，将氯胺酮 - 地西泮（120 mg/kg盐酸氯胺酮[5%]和2 mg/kg地西泮[5%]）、氯胺酮 - 乙酰丙嗪（120 mg/kg盐酸氯胺酮[5%]和1 mg/kg乙酰丙嗪[1%]）以及氯胺酮 - 赛拉嗪（120 mg/kg盐酸氯胺酮[5%]和1 mg/kg赛拉嗪[2%]）肌肉注射。测量麻醉起效时间和恢复时间。使用单因素方差分析和t检验对数据进行统计分析，P < 0.05被认为具有统计学意义。

结果

根据所使用的治疗方法，三种药物组合在麻醉起效时间和恢复时间的平均值上存在统计学显著差异。与氯胺酮 - 乙酰丙嗪组合相比，氯胺酮 - 地西泮组合治疗的动物，雄性和雌性龟的麻醉起效时间分别缩短了60%和42%，比氯胺酮 - 赛拉嗪组合治疗的动物缩短了64%（雄性龟）和50%（雌性龟）。此外，在雄性龟中，第一种药物组合治疗的动物恢复时间比氯胺酮 - 乙酰丙嗪组合治疗的动物缩短了17%，比氯胺酮 - 赛拉嗪组合治疗的动物缩短了37%。在雌性龟中，不同治疗方法之间的恢复时间似乎没有显著差异。