注射用麻醉剂不同组合在BALB/c小鼠中的安全性和有效性。
Safety and efficacy of various combinations of injectable anesthetics in BALB/c mice.
作者信息
Buitrago Sandra, Martin Thomas E, Tetens-Woodring Joanne, Belicha-Villanueva Alan, Wilding Gregory E
机构信息
Department of Laboratory Animal Resources, Roswell Park Cancer institute, Buffalo, NY, USA.
出版信息
J Am Assoc Lab Anim Sci. 2008 Jan;47(1):11-7.
Abstract
Four combinations of drugs--ketamine-xylazine, ketamine-xylazine-acepromazine (KXA), ketamine-xylazine-buprenorphine, and ketamine-xylazine-carprofen--were compared for their ability to produce anesthesia in BALB/c mice. Induction time, anesthetic duration, blood pressure, pulse rate, and time to recovery were recorded. The anesthesia induced by each anesthetic combination was assessed by using reflex responses to standardized stimuli. The KXA combination produced stable physiologic parameters and was associated with the longest duration of anesthesia (40 +/- 8 min); immobility was produced in all other groups (38 +/- 5 min), but a surgical plane of anesthesia could not be confirmed. All anesthetic protocols produced significant hypotension. No deaths occurred. We recommend KXA as a safe and reliable anesthetic for mice requiring a surgical plane of anesthesia.
摘要
比较了四种药物组合——氯胺酮-赛拉嗪、氯胺酮-赛拉嗪-乙酰丙嗪（KXA）、氯胺酮-赛拉嗪-丁丙诺啡和氯胺酮-赛拉嗪-卡洛芬——对BALB/c小鼠产生麻醉的能力。记录诱导时间、麻醉持续时间、血压、脉搏率和恢复时间。通过对标准化刺激的反射反应评估每种麻醉组合诱导的麻醉效果。KXA组合产生稳定的生理参数，且与最长麻醉持续时间（40±8分钟）相关；其他所有组均产生了不动状态（38±5分钟），但无法确认达到手术麻醉平面。所有麻醉方案均导致显著低血压。无死亡发生。我们推荐KXA作为需要达到手术麻醉平面的小鼠的一种安全可靠的麻醉剂。
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