Ali Shahrukh, Omer Muhammad Ovais, Chaudhry Mueen Ahmad, Ashraf Muhammad, Bukhsh Allah
Department of Pharmacology and Toxicology, University of Veterinary and Animal Sciences, Lahore, 54000, Punjab, Pakistan.
Department of Pharmacology, Faculty of Pharmacy, The University of Lahore, Lahore, 54000, Punjab, Pakistan.
Indian J Pharmacol. 2017 Jan-Feb;49(1):98-101. doi: 10.4103/0253-7613.201017.
The study was designed to evaluate possible antihistaminic and anticholinergic activities of .
Effects of crude ethanolic (Ed.Eth) and effects of crude aqueous (Ed.Aq) extracts of were studied using isolated guinea pig ileum, rabbit jejunum, and rabbit trachea. Tissue responses were recorded using isotonic and isometric transducers, connected with PowerLab data acquisition system.
A dose-dependent (0.1-0.3 mg/ml) rightward shift was demonstrated in histamine concentration-response curves. Whereas a complete relaxation of carbachol (1 μM)-induced contractions in isolated rabbit jejunum (3 mg/ml) and tracheal (10 mg/ml) preparations was observed, similar to dicyclomine at 1 and 3 μM, respectively. However, no significant difference between the effects of Ed.Eth and Ed.Aq was observed.
Study provides pharmacological evidence for the presence of antihistaminic and anticholinergic activities in crude extracts of and also highlight its medicinal significance in the management of airway and gastrointestinal disorders.
本研究旨在评估[具体物质]可能的抗组胺和抗胆碱能活性。
使用离体豚鼠回肠、兔空肠和兔气管，研究了[具体物质]的粗乙醇提取物（Ed.Eth）和粗水提取物（Ed.Aq）的作用。使用与PowerLab数据采集系统相连的等张和等长换能器记录组织反应。
组胺浓度-反应曲线呈现剂量依赖性（0.1 - 0.3 mg/ml）右移。在离体兔空肠（3 mg/ml）和气管（10 mg/ml）制剂中，观察到卡巴胆碱（1 μM）诱导的收缩完全松弛，分别类似于1 μM和3 μM的双环维林。然而，未观察到Ed.Eth和Ed.Aq作用之间的显著差异。
该研究为[具体物质]粗提取物中存在抗组胺和抗胆碱能活性提供了药理学证据，并突出了其在气道和胃肠道疾病管理中的医学意义。
