Maddala Raja Naga Mahesh, Ashwal A J, Rao M Sudhakar, Padmakumar R
Department of Medicine, Manipal University, Manipal, Udupi, Karnataka, India.
Department of Cardiology, KMC, Manipal University, Manipal, Udupi, Karnataka, India.
Indian J Pharmacol. 2017 Jan-Feb;49(1):127-129. doi: 10.4103/ijp.IJP_204_16.
Lithium is a commonly used drug in psychiatric practice. It is used in the treatment of depression and bipolar disorder. It has a narrow therapeutic index with documented adverse effects even near therapeutic levels. It has myriad of manifestations at toxic levels. The cardiovascular effects range from relatively benign ST-T wave changes to fatal arrhythmias. We describe a case of lithium toxicity which presented as a junctional rhythm and later showed a variety of manifestations such as complete heart block, atrial fibrillation, sinus bradycardia, and finally reverted to sinus rhythm at par with serum lithium levels.
锂是精神科临床常用药物。它用于治疗抑郁症和双相情感障碍。其治疗指数狭窄,即使在接近治疗水平时也有已记录的不良反应。在中毒水平时会有多种表现。心血管方面的影响从相对良性的ST-T波改变到致命性心律失常。我们描述了一例锂中毒病例,该病例最初表现为交界性心律,随后出现了多种表现,如完全性心脏传导阻滞、心房颤动、窦性心动过缓,最终随着血清锂水平下降恢复为窦性心律。