Rong Dawei, Tang Weiwei, Li Zhouxiao, Zhou Jian, Shi Junfeng, Wang Hanjin, Cao Hongyong
Department of General Surgery, Nanjing First Hospital, Nanjing Medical University, Nanjing, Jiangsu, People's Republic of China.
Department of Plastic and Hand Surgery, University Hospital Munich, Munich, Germany.
Onco Targets Ther. 2017 Apr 18;10:2183-2188. doi: 10.2147/OTT.S134403. eCollection 2017.
Circular RNAs (circRNAs), formed by nonsequential back-splicing of pre-messenger RNA (pre-mRNA) transcripts, have been widely concerned in recent years. With advances in high-throughput RNA sequencing (RNA-seq) technology, previous work has revealed that a large number of circRNAs, which are endogenous, abundant and stable in mammalian cells, may be involved in atherosclerotic vascular disease risk, neurological disorders, prion diseases and carcinomas. Remarkably, interaction between circRNAs and microRNA has already been observed to perform a significant role in a variety of cancers, including gastric cancer and colorectal cancer. Recent work has suggested that circRNAs may play critical roles in the initiation and development of cancers and could become potential new biomarkers for cancers. Herein, we review the current understanding of the roles of circRNAs in cancers and the potential implications of circRNAs in cancer-targeted therapy.
环状RNA（circRNAs）由信使核糖核酸前体（pre-mRNA）转录本的非顺序反向剪接形成，近年来受到广泛关注。随着高通量RNA测序（RNA-seq）技术的进步，先前的研究表明，大量在哺乳动物细胞中内源性、丰富且稳定的circRNAs可能与动脉粥样硬化性血管疾病风险、神经疾病、朊病毒病和癌症有关。值得注意的是，已经观察到circRNAs与微小RNA之间的相互作用在包括胃癌和结直肠癌在内的多种癌症中发挥重要作用。最近的研究表明，circRNAs可能在癌症的发生和发展中起关键作用，并可能成为癌症潜在的新生物标志物。在此，我们综述了目前对circRNAs在癌症中作用的理解以及circRNAs在癌症靶向治疗中的潜在意义。
