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血小板激活因子作为与严重 COVID-19 相关发病率和死亡率的潜在因素的综述。

A Review of Platelet-Activating Factor As a Potential Contributor to Morbidity and Mortality Associated with Severe COVID-19.

机构信息

20040Minneapolis Veterans Affairs Healthcare System, Minneapolis, MN, 55417, USA.

University of Minnesota, MN, USA.

出版信息

Clin Appl Thromb Hemost. 2021 Jan-Dec;27:10760296211051764. doi: 10.1177/10760296211051764.

DOI:10.1177/10760296211051764
PMID:34755565
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8586171/
Abstract

The precise mechanisms of pathology in severe COVID-19 remains elusive. Current evidence suggests that inflammatory mediators are responsible for the manifestation of clinical symptoms that precedes a fatal response to infection. This review examines the nature of platelet activating factor and emphasizes the similarities between the physiological effects of platelet activating factor and the clinical complications of severe COVID-19.

摘要

严重 COVID-19 中病理学的确切机制仍难以捉摸。目前的证据表明，炎症介质是导致感染后致命反应之前出现临床症状的原因。本文回顾了血小板激活因子的性质，并强调了血小板激活因子的生理作用与严重 COVID-19 的临床并发症之间的相似性。

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本文引用的文献

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COVID-19, microthromboses, inflammation, and platelet activating factor.COVID-19、微血栓、炎症和血小板激活因子。
Biofactors. 2020 Nov;46(6):927-933. doi: 10.1002/biof.1696. Epub 2020 Dec 9.
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Registry of Arterial and Venous Thromboembolic Complications in Patients With COVID-19.COVID-19 患者的动脉和静脉血栓栓塞并发症登记册。
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Aspirin Use Is Associated With Decreased Mechanical Ventilation, Intensive Care Unit Admission, and In-Hospital Mortality in Hospitalized Patients With Coronavirus Disease 2019.
埃博拉病毒样颗粒重编程细胞代谢。
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Plasmalogenic Lipid Analogs as Platelet-Activating Factor Antagonists: A Potential Novel Class of Anti-inflammatory Compounds.缩醛磷脂类似物作为血小板活化因子拮抗剂：一类潜在的新型抗炎化合物。
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Sex-Related Factors in Cardiovascular Complications Associated to COVID-19.与 COVID-19 相关心血管并发症的性别因素。
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