Reimann Ronny, Kost Benedikt, Dettmer Jan
Cell Biology, Biology Department, Friedrich-Alexander University Erlangen-NurembergErlangen, Germany.
Front Plant Sci. 2017 Apr 18;8:545. doi: 10.3389/fpls.2017.00545. eCollection 2017.
Tetraspanins are small transmembrane proteins that laterally associate with each other and cluster with numerous partner proteins as well as lipids. These interactions result in the formation of a distinct class of membrane domains, the tetraspanin-enriched microdomains (TEMs), which influence numerous cellular processes such as cell adhesion and fusion, intracellular membrane trafficking, signaling, morphogenesis, motility as well as interaction with pathogens and cancer development. The majority of information available about tetraspanins is based on studies using animal models or cell lines, but tetraspanins are also present in fungi and plants. Recent studies indicate that tetraspanins have important functions in plant development, reproduction and stress responses. Here we provide a brief summary of the current state of tetraspanin research in plants.
四跨膜蛋白是一类小的跨膜蛋白，它们彼此侧向关联，并与众多伴侣蛋白以及脂质聚集在一起。这些相互作用导致形成一类独特的膜结构域，即富含四跨膜蛋白的微结构域（TEMs），其影响众多细胞过程，如细胞黏附与融合、细胞内膜运输、信号传导、形态发生、运动性以及与病原体的相互作用和癌症发展。目前关于四跨膜蛋白的大多数信息基于使用动物模型或细胞系的研究，但四跨膜蛋白也存在于真菌和植物中。最近的研究表明，四跨膜蛋白在植物发育、繁殖和应激反应中具有重要功能。在此，我们简要概述植物中四跨膜蛋白研究的现状。
