Farkas Johanna E, Monaghan James R
Department of Biology, Northeastern University, Boston, MA, USA.
Neurogenesis (Austin). 2017 Apr 10;4(1):e1302216. doi: 10.1080/23262133.2017.1302216. eCollection 2017.
Nerve dependence is a phenomenon observed across a stunning array of species and tissues. From zebrafish to fetal mice to humans, research across various animal models has shown that nerves are critical for the support of tissue repair and regeneration. Although the study of this phenomenon has persisted for centuries, largely through research conducted in salamanders, the cellular and molecular mechanisms of nerve dependence remain poorly-understood. Here we highlight the near-ubiquity and clinical relevance of vertebrate nerve dependence while providing a timeline of its study and an overview of recent advancements toward understanding the mechanisms behind this process. In presenting a brief history of the research of nerve dependence, we provide both historical and modern context to our recent work on nerve dependent limb regeneration in the Mexican axolotl.
神经依赖性是在一系列令人惊叹的物种和组织中观察到的一种现象。从斑马鱼到胎鼠再到人类，对各种动物模型的研究表明，神经对于组织修复和再生的支持至关重要。尽管对这一现象的研究已经持续了几个世纪，主要是通过对蝾螈的研究，但神经依赖性的细胞和分子机制仍知之甚少。在这里，我们强调脊椎动物神经依赖性的几乎普遍性和临床相关性，同时提供其研究的时间线以及对理解这一过程背后机制的最新进展的概述。在介绍神经依赖性研究的简史时，我们为我们最近关于墨西哥钝口螈神经依赖性肢体再生的研究提供了历史和现代背景。
