Kulkarni Varun, Uttamani Juhi Raju, Naqvi Afsar Raza, Nares Salvador
1 Department of Periodontics, College of Dentistry, The University of Illinois at Chicago, Chicago, IL, USA.
Tumour Biol. 2017 May;39(5):1010428317698379. doi: 10.1177/1010428317698379.
Association of oral diseases and disorders with altered microRNA profiles is firmly recognized. These evidences support the potential use of microRNAs as therapeutic tools for diagnosis, prognosis, and treatment of various diseases. In this review, we highlight the association of altered microRNA signatures in oral cancers and oral inflammatory diseases. Advances in our ability to detect microRNAs in human sera and saliva further highlight their clinical value as potential biomarkers. We have discussed key mechanisms underlying microRNA dysregulation in pathological conditions. The use of microRNAs in diagnostics and their potential therapeutic value in the treatment of oral diseases are reviewed.
口腔疾病与失调的微小RNA谱之间的关联已得到明确认可。这些证据支持将微小RNA作为诊断、预后和治疗各种疾病的治疗工具的潜在用途。在本综述中，我们重点介绍口腔癌和口腔炎性疾病中微小RNA特征改变的关联。我们在检测人血清和唾液中微小RNA能力方面的进展进一步凸显了它们作为潜在生物标志物的临床价值。我们讨论了病理条件下微小RNA失调的关键机制。本文综述了微小RNA在诊断中的应用及其在口腔疾病治疗中的潜在治疗价值。
