Moran-Lev Hadar, Lubetzky Ronit, Mandel Dror, Yerushalmy-Feler Anat, Cohen Shlomi
1 Department of Pediatrics, Dana Dwek Children's Hospital, Tel Aviv Medical Center, affiliated to the Sackler Faculty of Medicine, Tel Aviv University , Tel Aviv, Israel .
2 The Pediatric Gastroenterology Unit, Dana Dwek Children's Hospital, Tel Aviv Medical Center, affiliated to the Sackler Faculty of Medicine, Tel Aviv University , Tel Aviv, Israel .
Child Obes. 2017 Aug;13(4):267-271. doi: 10.1089/chi.2016.0275. Epub 2017 May 1.
Helicobacter pylori, one of the most common bacterial pathogens in humans, is generally acquired during childhood. The inverse correlation between H. pylori colonization and obesity that was found in adults has not been investigated in depth in children. Our aim was to assess the correlation between overweight and obesity and H. pylori colonization in a pediatric population.
H. pylori colonization in 70 symptomatic children was determined after antral biopsies during esophagogastroduodenoscopy. Data on anthropometric measurements, sociodemographic characteristics, and medical history were recorded.
The participants' mean age was 12.41 ± 3.16 years, 58% were females, and 24% were obese or overweight (BMI >85th percentile). The H. pylori colonization rate was 31%. There were no significant differences between the H. pylori-infected and H. pylori-noninfected groups in terms of age, gender, or clinical and sociodemographic characteristics. Nevertheless, the prevalence of overweight and obesity was significantly lower in children with H. pylori colonization compared to children with normal histology (31% in the noninfected group compared to 11% in the infected group, p = 0.04). The mean fat percentage was 24.3 ± 8.8 and 19.4 ± 6.9, respectively (p = 0.02).
The findings of this prospective study are in agreement with previous studies and demonstrate an inverse relationship between H. pylori colonization and overweight or obesity among symptomatic children. A larger prospective, multiethnic investigation is warranted to more definitively determine the extent of this association.
幽门螺杆菌是人类最常见的细菌病原体之一，通常在儿童时期感染。幽门螺杆菌定植与成人肥胖之间的负相关关系在儿童中尚未得到深入研究。我们的目的是评估儿科人群中超重、肥胖与幽门螺杆菌定植之间的相关性。
在70例有症状儿童进行食管胃十二指肠镜检查时，取胃窦活检组织，确定幽门螺杆菌定植情况。记录人体测量数据、社会人口学特征和病史。
参与者的平均年龄为12.41±3.16岁，58%为女性，24%为肥胖或超重（BMI>第85百分位数）。幽门螺杆菌定植率为31%。幽门螺杆菌感染组和未感染组在年龄、性别、临床及社会人口学特征方面无显著差异。然而，与组织学正常的儿童相比，幽门螺杆菌定植儿童的超重和肥胖患病率显著较低（未感染组为31%，感染组为11%，p=0.04）。平均脂肪百分比分别为24.3±8.8和19.4±6.9（p=0.02）。
这项前瞻性研究的结果与之前的研究一致，表明有症状儿童中幽门螺杆菌定植与超重或肥胖之间存在负相关关系。需要进行更大规模的前瞻性、多民族调查，以更明确地确定这种关联的程度。
