Faculty of Medicine, Hebrew University of Jerusalem, Jerusalem, Israel.
Pediatric Gastroenterology, Kaplan Medical Center, Rehovot, Israel.
Helicobacter. 2020 Oct;25(5):e12728. doi: 10.1111/hel.12728. Epub 2020 Jul 19.
The reduction in the prevalence of Helicobacter pylori (H. pylori) infection in developed countries coincides with the increasing incidence of obesity and might be a contributing factor to the obesity epidemic. We aimed to evaluate the association between H. pylori infection and childhood overweight/ obesity in Israeli children.
Patients diagnosed with H. pylori infection by endoscopy, histology, and a positive culture, between January 2013 and August 2018, were identified and compared with H. pylori-negative children, of the same age and gender, undergoing endoscopy for the same indications during the same time period. Data collected included the following: age, gender, height, weight, BMI, BMI percentile, and the indication for endoscopy. Patients with missing anthropometric data or having a disease affecting growth were excluded.
We included 146 H. pylori-positive children and 146 age- and gender-matched H. pylori-negative patients. 63.7% (186/292) were female, mean age 13.1 ± 3.7. Overweight (BMI between the 85th-95th percentile) and obesity (BMI > 95th percentile) were present in 56/292 (19.2%). Among the H. pylori-positive children, 11.6% were overweight, 7.5% obese, among the H. pylori-negative children, 10.3% were overweight, 8.9% obese, demonstrating no differences between the groups. The main indication for endoscopy was abdominal/ epigastric pain in 79.8% (233/292). The percent of children with a BMI ≥ 85% did not differ by gender age or the indication for endoscopy.
No association between H. pylori infection and childhood overweight/ obesity was demonstrated. This is in contrasts with previous pediatric studies demonstrating an inverse correlation.
在发达国家，幽门螺杆菌 (H. pylori) 感染率的降低与肥胖症发病率的上升相吻合，可能是肥胖症流行的一个促成因素。我们旨在评估以色列儿童中 H. pylori 感染与儿童超重/肥胖之间的关系。
通过内镜检查、组织学和阳性培养诊断为 H. pylori 感染的患者，在 2013 年 1 月至 2018 年 8 月期间被确定，并与在同一时期因相同适应症接受内镜检查的 H. pylori 阴性儿童进行比较。收集的数据包括：年龄、性别、身高、体重、BMI、BMI 百分位和内镜检查的适应症。排除了缺少人体测量数据或患有影响生长的疾病的患者。
我们纳入了 146 例 H. pylori 阳性儿童和 146 例年龄和性别匹配的 H. pylori 阴性患者。146 例患者中，63.7%（186/292）为女性，平均年龄 13.1±3.7 岁。超重（BMI 在第 85-95 百分位之间）和肥胖（BMI>第 95 百分位）分别占 56/292（19.2%）。在 H. pylori 阳性儿童中，11.6%超重，7.5%肥胖，在 H. pylori 阴性儿童中，10.3%超重，8.9%肥胖，两组之间无差异。内镜检查的主要适应症是腹部/上腹部疼痛，占 79.8%（233/292）。BMI≥85%的儿童比例与性别、年龄或内镜检查的适应症无关。
H. pylori 感染与儿童超重/肥胖之间没有关联。这与之前的儿科研究表明的相反。
