Brief Funct Genomics. 2017 Nov 1;16(6):348-360. doi: 10.1093/bfgp/elx004.
Cancer burden rises globally at an alarming pace. According to GLOBOCAN 2012, gastric cancer (GC) is regarded as the fifth most common malignancy in the world. Being twice as high in men as in women, GC is the third leading cause of cancer mortality in both sexes globally. Being labeled as 'junk DNA', pseudogenes were considered as nonfunctional 'trash', which contribute nothing to survival of the organism; therefore, a number of strategies have been developed to circumvent their accidental detection. Recent progresses have confirmed that pseudogenes can have broad and multifaceted spectrum of activities in human cancers in general and GC in particular. Furthermore, the mentioned functions are parental gene-dependent and/or -independent. Therefore, pseudogenes can be regarded as the emerging class of elaborate modulators of gene expression involved in pathogenesis of human cancers including gastric adenocarcinoma.
癌症负担在全球范围内以惊人的速度上升。根据 GLOBOCAN 2012 年的数据，胃癌（GC）被认为是全球第五种最常见的恶性肿瘤。男性的发病率是女性的两倍，GC 是全球男女癌症死亡的第三大主要原因。假基因被标记为“垃圾 DNA”，被认为是没有功能的“垃圾”，对生物体的生存没有任何贡献；因此，已经开发了许多策略来避免它们的偶然检测。最近的进展证实，假基因通常可以在人类癌症中具有广泛而多方面的活性，特别是在 GC 中。此外，所述功能是依赖于亲代基因的和/或独立的。因此，假基因可以被视为参与包括胃腺癌在内的人类癌症发病机制的精细基因表达调控的新兴类别。
