Isolation of a Virulent Strain from and Characterization by Whole-Genome Sequence Analysis.

() is an important veterinary pathogen and a noteworthy threat to human and animal health. Recently, there has been a significant rise in the number of moose fatalities caused by this rare, endemic species in China. Currently, there is an increasing trend in conducting whole-genome analysis of strains originating from pigs and chickens, whereas fewer studies have been undertaken on -originating strains at the whole-genome level. Our laboratory has identified and isolated five type A from affected The current study identified the most potent strain of which originated from , and sequenced its genome to reveal virulence genes and pathogenicity. Our findings show that strain CX1-4 exhibits the highest levels of phospholipase activity, hemolytic activity, and mouse toxicity compared to the other four isolated type A strains. The chromosome sequence length of the CX1-4 strain was found to be 3,355,389 bp by complete genome sequencing. The current study unveils the genomic characteristics of type A originating from . It provides a core foundation for further investigation regarding the prevention and treatment of such infectious diseases in .