Zhang Zhao, Wang Xiao, Li Siyuan, Fu Yuhang, Li Yan, Nawaz Shah, Chen Jing, Yang Guoxiang, Li Jiakui, Shi Daoliang
College of Veterinary Medicine, Huazhong Agricultural University, Wuhan 430070, China.
Hubei Provincial Wildlife Rescue Center, Wuhan 430070, China.
Curr Issues Mol Biol. 2024 Jul 8;46(7):7169-7186. doi: 10.3390/cimb46070427.
() is an important veterinary pathogen and a noteworthy threat to human and animal health. Recently, there has been a significant rise in the number of moose fatalities caused by this rare, endemic species in China. Currently, there is an increasing trend in conducting whole-genome analysis of strains originating from pigs and chickens, whereas fewer studies have been undertaken on -originating strains at the whole-genome level. Our laboratory has identified and isolated five type A from affected The current study identified the most potent strain of which originated from , and sequenced its genome to reveal virulence genes and pathogenicity. Our findings show that strain CX1-4 exhibits the highest levels of phospholipase activity, hemolytic activity, and mouse toxicity compared to the other four isolated type A strains. The chromosome sequence length of the CX1-4 strain was found to be 3,355,389 bp by complete genome sequencing. The current study unveils the genomic characteristics of type A originating from . It provides a core foundation for further investigation regarding the prevention and treatment of such infectious diseases in .
（）是一种重要的兽医病原体，对人类和动物健康构成重大威胁。最近，在中国，这种罕见的地方物种导致的驼鹿死亡数量显著增加。目前，对源自猪和鸡的菌株进行全基因组分析的数量呈上升趋势，而对源自（此处原文有缺失信息）的菌株在全基因组水平上的研究较少。我们实验室从受影响的（此处原文有缺失信息）中鉴定并分离出五株A型（此处原文有缺失信息）。当前研究鉴定出源自（此处原文有缺失信息）的最具毒性的（此处原文有缺失信息）菌株，并对其基因组进行测序以揭示毒力基因和致病性。我们的研究结果表明，与其他四株分离出的A型（此处原文有缺失信息）菌株相比，CX1 - 4菌株表现出最高水平的磷脂酶活性、溶血活性和小鼠毒性。通过全基因组测序发现CX1 - 4菌株的染色体序列长度为3,355,389 bp。当前研究揭示了源自（此处原文有缺失信息）的A型（此处原文有缺失信息）的基因组特征。它为进一步研究（此处原文有缺失信息）此类传染病的预防和治疗提供了核心基础。
