Institute of Biochemistry II, School of Medicine, Goethe University, 60598 Frankfurt am Main, Germany; email:
Buchmann Institute for Molecular Life Sciences, Goethe University, 60438 Frankfurt am Main, Germany.
Annu Rev Biochem. 2017 Jun 20;86:193-224. doi: 10.1146/annurev-biochem-061516-044908. Epub 2017 May 1.
Autophagy and the ubiquitin-proteasome system are the two major quality control pathways responsible for cellular homeostasis. As such, they provide protection against age-associated changes and a plethora of human diseases. Ubiquitination is utilized as a degradation signal by both systems, albeit in different ways, to mark cargoes for proteasomal and lysosomal degradation. Both systems intersect and communicate at multiple points to coordinate their actions in proteostasis and organelle homeostasis. This review summarizes molecular details of how proteasome and autophagy pathways are functionally interconnected in cells and indicates common principles and nodes of communication that can be therapeutically exploited.
自噬和泛素-蛋白酶体系统是负责细胞内稳态的两个主要质量控制途径。因此，它们为对抗与年龄相关的变化和众多人类疾病提供了保护。泛素化被两个系统用作降解信号，尽管方式不同，但它将货物标记为蛋白酶体和溶酶体降解的目标。这两个系统在多个点交叉和交流，以协调它们在蛋白质稳态和细胞器内稳态中的作用。这篇综述总结了细胞中蛋白酶体和自噬途径如何在功能上相互连接的分子细节，并指出了可以在治疗中利用的共同原则和交流节点。
