Newton Michael D, Osborne Jeffrey, Gawronski Karissa, Baker Kevin C, Maerz Tristan
Orthopaedic Research Laboratory, Beaumont Health, Royal Oak, Michigan.
Department of Orthopaedic Surgery, Beaumont Health, Royal Oak, Michigan.
J Orthop Res. 2017 Dec;35(12):2755-2764. doi: 10.1002/jor.23588. Epub 2017 May 23.
Current imaging-based morphometric indicators of osteoarthritis (OA) using whole-compartment mean cartilage thickness (MCT) and volume changes can be insensitive to mild degenerative changes of articular cartilage (AC) due to areas of adjacent thickening and thinning. The purpose of this preliminary study was to evaluate cartilage thickness-based surface roughness as a morphometric indicator of OA. 3D magnetic resonance imaging (MRI) datasets were collected from osteoarthritis initiative (OAI) subjects with Kellgren-Lawrence (KL) OA grades of 0, 2, and 4 (n = 10/group). Femoral and tibial AC volumes were converted to two-dimensional thickness maps, and MCT, arithmetic surface roughness (S ), and anatomically normalized S (normS ) were calculated. Thickness maps enabled visualization of degenerative changes with increasing KL grade, including adjacent thinning and thickening on the femoral condyles. No significant differences were observed in MCT between KL grades. S was significantly higher in KL4 compared to KL0 and KL2 in the whole femur (KL0: 0.55 ± 0.10 mm, KL2: 0.53 ± 0.09 mm, KL4: 0.79 ± 0.18 mm), medial femoral condyle (KL0: 0.42 ± 0.07 mm, KL2: 0.48 ± 0.07 mm, KL4: 0.76 ± 0.22 mm), and medial tibial plateau (KL0: 0.42 ± 0.07 mm, KL2: 0.43 ± 0.09 mm, KL4: 0.68 ± 0.27 mm). normS was significantly higher in KL4 compared to KL0 and KL2 in the whole femur (KL0: 0.22 ± 0.02, KL2: 0.22 ± 0.02, KL4: 0.30 ± 0.03), medial condyle (KL0: 0.17 ± 0.02, KL2: 0.20 ± 0.03, KL4: 0.29 ± 0.06), whole tibia (KL0: 0.34 ± 0.04, KL2: 0.33 ± 0.05, KL4: 0.48 ± 0.11) and medial plateau (KL0: 0.23 ± 0.03, KL2: 0.24 ± 0.04, KL4: 0.40 ± 0.10), and significantly higher in KL2 compared to KL0 in the medial femoral condyle. Surface roughness metrics were sensitive to degenerative morphologic changes, and may be useful in OA characterization and early diagnosis. © 2017 Orthopaedic Research Society. Published by Wiley Periodicals, Inc. J Orthop Res 35:2755-2764, 2017.
目前基于成像的骨关节炎（OA）形态测量指标，使用全关节软骨平均厚度（MCT）和体积变化，由于存在相邻增厚和变薄区域，可能对关节软骨（AC）的轻度退行性变化不敏感。本初步研究的目的是评估基于软骨厚度的表面粗糙度作为OA的形态测量指标。从骨关节炎倡议（OAI）研究对象中收集三维磁共振成像（MRI）数据集，这些对象的Kellgren-Lawrence（KL）OA分级为0、2和4级（每组n = 10）。将股骨和胫骨的AC体积转换为二维厚度图，并计算MCT、算术表面粗糙度（S）和解剖学标准化S（normS）。厚度图能够显示随着KL分级增加的退行性变化，包括股骨髁的相邻变薄和增厚。KL分级之间的MCT未观察到显著差异。在整个股骨中，KL4级的S显著高于KL0和KL2级（KL0：0.55±0.10mm，KL2：0.53±0.09mm，KL4：0.79±0.18mm），在内侧股骨髁（KL0：0.42±0.07mm，KL2：0.48±0.07mm，KL4：0.76±0.22mm）和内侧胫骨平台（KL0：0.42±0.07mm，KL2：0.43±0.09mm，KL4：0.68±0.27mm）也是如此。在整个股骨中，KL4级的normS显著高于KL0和KL2级（KL0：0.22±0.02，KL2：0.22±0.02，KL4：0.30±0.03），在内侧髁（KL0：0.17±0.02，KL2：0.20±0.03，KL4：0.29±0.06）、整个胫骨（KL0：0.34±0.04，KL2：0.33±0.05，KL4：0.48±0.11）和内侧平台（KL0：0.23±0.03，KL2：0.24±0.04，KL4：0.40±0.10）也是如此，并且在内侧股骨髁中，KL2级的normS显著高于KL0级。表面粗糙度指标对退行性形态变化敏感，可能有助于OA的特征描述和早期诊断。©2017骨科学研究协会。由Wiley Periodicals, Inc.出版。《矫形外科学研究杂志》35：2755 - 2764，2017年。
