产生白细胞介素-10的调节性B细胞在银屑病关节炎和银屑病中功能受损，且与产生白细胞介素-17和干扰素γ的T细胞呈负相关。
IL-10 producing Bregs are impaired in psoriatic arthritis and psoriasis and inversely correlate with IL-17- and IFNγ-producing T cells.
作者信息
Mavropoulos Athanasios, Varna Areti, Zafiriou Efterpi, Liaskos Christos, Alexiou Ioannis, Roussaki-Schulze Aggeliki, Vlychou Marianna, Katsiari Christina, Bogdanos Dimitrios P, Sakkas Lazaros I
机构信息
Department of Rheumatology and Clinical Immunology, Faculty of Medicine, School of Health Sciences, University of Thessaly, Larissa 41 110, Greece.
Department of Dermatology, Faculty of Medicine, School of Health Sciences, University of Thessaly, Larissa 41 110, Greece.
出版信息
Clin Immunol. 2017 Nov;184:33-41. doi: 10.1016/j.clim.2017.04.010. Epub 2017 Apr 28.
Our aim was to study CD19(+)CD27(+)CD24(high) memory and CD19(+)CD24(high)CD38(high) transitional and IL-10+Breg cells, known to inhibit Th1 and Th17 cells in experimental arthritis, in psoriatic arthritis (PsA) and psoriasis (Ps). Peripheral blood Breg cells from 60 patients with PsA, 50 patients with Ps and 23 healthy controls were analyzed by flow cytometry. IL-17A-producing CD3(+) T cells and IFNγ-producing CD3(+) T cells and activation of p38 MAPK and STAT3 were also studied. CD19(+)CD27(+)CD24(high) and CD19(+)CD24(high)CD38(high) Breg cells were decreased in PsA and Ps. In Ps patients, CD19(+)CD27(+)CD24(high) Breg cells inversely correlated with PASI score. IL-10+Bcells were also decreased and inversely correlated with IL-17A+CD3+ and IFN-γ+CD3+ T cells. B cells from patients exhibited impaired activation of p38 MAPK and STAT3. In conclusion, IL-10+Breg cells are decreased PsA and Ps and inversely correlated with the severity of psoriasis and IL-17A+ and IFNγ+ T cells.
我们的目的是研究CD19(+)CD27(+)CD24(高表达)记忆性细胞、CD19(+)CD24(高表达)CD38(高表达)过渡性细胞以及IL-10+B调节细胞（已知这些细胞在实验性关节炎中可抑制Th1和Th17细胞）在银屑病关节炎（PsA）和银屑病（Ps）中的情况。通过流式细胞术分析了60例PsA患者、50例Ps患者和23名健康对照者外周血中的B调节细胞。还研究了产生IL-17A的CD3(+)T细胞、产生IFNγ的CD3(+)T细胞以及p38丝裂原活化蛋白激酶（p38 MAPK）和信号转导及转录激活因子3（STAT3）的激活情况。PsA和Ps患者中CD19(+)CD27(+)CD24(高表达)和CD19(+)CD24(高表达)CD38(高表达)B调节细胞减少。在Ps患者中，CD19(+)CD27(+)CD24(高表达)B调节细胞与银屑病面积和严重程度指数（PASI）评分呈负相关。IL-10+B细胞也减少，且与IL-17A+CD3+和IFN-γ+CD3+T细胞呈负相关。患者的B细胞表现出p38 MAPK和STAT3激活受损。总之，IL-10+B调节细胞在PsA和Ps中减少，且与银屑病严重程度、IL-17A+和IFNγ+T细胞呈负相关。
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