Blaheta Roman A, Oertl Anton, Freisleben Hans-Joachim, Nelson Karen, Ackermann Hanns, Haferkamp Axel, Engl Tobias
Department of Urology, Goethe University, Frankfurt am Main, Germany.
equal author contribution.
Cent European J Urol. 2017;70(1):107-111. doi: 10.5173/ceju.2017.912. Epub 2017 Mar 14.
Ureter obstruction caused by a retro-peritoneal tumor is treated by inserting an indwelling ureter splint (DJ-stent). Indwelling duration is limited by cumulative crystalline deposits into the splint, eventually causing the repeated impairment of urine flow. Deciding when a DJ-stent must be replaced is important since belated removal can be accompanied by severe complications. X-ray or conventional sonography do not allow satisfactory evaluation of early incrustation, therefore, the use of sonographic twinkling artifacts (TA) to provide accurate stent surveillance was investigated.
26 patients with indwelling ureter splints carrying a high risk of developing tumor lysis syndrome (TLS), which is often accompanied by early splint incrustation, were investigated utilizing TA the day after DJ-stent implantation and weekly thereafter. Serum creatinine, uric acid, and urine pH were measured at all TA exams.
Early incrustation of the ureter splint was detected by TA in all patients 1-4 weeks after implantation. Incrustation occurred sooner with increased uric acid levels, and high creatinine or acidic urine accelerated early implant incrustation.
TA can be used to monitor early crystalline deposits in implanted ureter splints, before they can be detected by conventional sonography or X-ray imaging and before complications occur.
腹膜后肿瘤导致的输尿管梗阻通过插入留置输尿管支架(DJ 支架)进行治疗。留置时间受支架内累积结晶沉积物的限制,最终会导致尿流反复受阻。确定何时必须更换 DJ 支架很重要,因为延迟取出可能会伴随严重并发症。X 线或传统超声检查无法对早期结垢进行令人满意的评估,因此,研究了使用超声闪烁伪像(TA)来进行准确的支架监测。
对 26 例携带高肿瘤溶解综合征(TLS)发生风险且常伴有早期支架结垢的留置输尿管支架患者,在植入 DJ 支架后第 1 天及之后每周利用 TA 进行检查。在所有 TA 检查时均测量血清肌酐、尿酸和尿液 pH 值。
在植入后 1 - 4 周内,所有患者均通过 TA 检测到输尿管支架早期结垢。尿酸水平升高时结垢出现得更早,高肌酐或酸性尿液会加速早期植入物结垢。
在传统超声检查或 X 线成像能够检测到植入的输尿管支架早期结晶沉积物之前以及并发症发生之前,TA 可用于监测这些沉积物。