Lee Jae-Hong, Choi Jung-Kyu, Kim Sang-Hyun, Cho Kyung-Hyun, Kim Young-Taek, Choi Seong-Ho, Jung Ui-Won
Department of Periodontology, Wonkwang University Daejeon Dental Hospital, Wonkwang University College of Dentistry, Daejeon, Korea.
Department of Health Insurance Research, Ilsan Hospital, National Health Insurance Service, Goyang, Korea.
J Periodontal Implant Sci. 2017 Apr;47(2):96-105. doi: 10.5051/jpis.2017.47.2.96. Epub 2017 Apr 29.
The National Health Insurance Service-National Sample Cohort and medical checkup data from 2002 to 2013 were used to evaluate the association between periodontal surgery for the treatment of periodontitis (PSTP) and vasculogenic erectile dysfunction (VED).
Bivariate and multivariate logistic regression analyses were applied to a longitudinal retrospective database to assess the association between PSTP and VED while adjusting for the potential confounding effects of sociodemographic factors (age, household income, insurance status, health status, residence area, and smoking status) and comorbidities (diabetes mellitus, angina pectoris, cerebral infarction, and myocardial infarction).
Among the 7,148 PSTP within the 268,296 recruited subjects, the overall prevalence of VED in PSTP was 1.43% (n=102). The bivariate analysis showed that VED was significantly related to PSTP (odds ratio [OR], 1.99; 95% confidence interval [CI], 1.38-2.06; <0.001), and this was confirmed in the multivariate analysis after adjusting for sociodemographic factors and comorbidities (OR, 1.29; 95% CI, 1.06-1.58; =0.002).
Subjects with a history of periodontal flap surgery had a significantly higher risk of VED, after adjusting for potential confounding factors. Further studies are required to identify the key mechanisms underlying the association between severe periodontal disease and VED.
利用2002年至2013年的国民健康保险服务-全国样本队列和体检数据，评估用于治疗牙周炎的牙周手术（PSTP）与血管性勃起功能障碍（VED）之间的关联。
对一个纵向回顾性数据库进行双变量和多变量逻辑回归分析，以评估PSTP与VED之间的关联，同时调整社会人口学因素（年龄、家庭收入、保险状况、健康状况、居住地区和吸烟状况）和合并症（糖尿病、心绞痛、脑梗死和心肌梗死）的潜在混杂效应。
在268,296名招募对象中的7,148例PSTP中，PSTP中VED的总体患病率为1.43%（n = 102）。双变量分析显示VED与PSTP显著相关（优势比[OR]，1.99；95%置信区间[CI]，1.38 - 2.06；<0.001），在调整社会人口学因素和合并症后的多变量分析中得到证实（OR，1.29；95% CI，1.06 - 1.58；=0.002）。
在调整潜在混杂因素后，有牙周翻瓣手术史的受试者患VED的风险显著更高。需要进一步研究以确定严重牙周疾病与VED之间关联的关键机制。
