Department of Periodontology, Daejeon Dental Hospital, Institute of Wonkwang Dental Research, College of Dentistry, Wonkwang University, Daejeon 35233, Korea.
Medicina (Kaunas). 2020 Oct 29;56(11):575. doi: 10.3390/medicina56110575.
This study determined the association between periodontal disease (PD) and major lifestyle-related comorbidities (LCs) using the database of the nationwide population-based National Health Insurance Service-Elderly Cohort 2002-2015. A nationwide representative sample comprising 558,147 participants, aged 60 years, was analyzed. Univariate and multivariate logistic regression analyses adjusted for sociodemographic and economic factors (sex, age, household income, insurance status, health status, and living area) and major LCs (hypertension, diabetes mellitus, rheumatoid arthritis, osteoporosis, cerebral infarction, angina pectoris, myocardial infarction, erectile dysfunction, lipoprotein disorder, and obesity) were used to determine the association between PD and major LCs. Elderly participants with PD had a higher risk of major LCs (hypertension: odds ratio (OR) = 1.40, diabetes mellitus: OR = 1.22, rheumatoid arthritis: OR = 1.16, osteoporosis: OR = 1.37, erectile dysfunction: OR = 1.73, lipoprotein disorder: OR = 1.50, and obesity: OR = 1.59). Our longitudinal cohort study provided evidence that PD was significantly associated with major LCs in elderly participants. In particular, the association between PD and erectile dysfunction had the highest OR in the multivariate analyses.
本研究利用全国性的基于人群的国民健康保险服务-老年人队列 2002-2015 年的数据库，确定了牙周病（PD）与主要生活方式相关合并症（LCs）之间的关联。分析了一个由 558147 名年龄在 60 岁的参与者组成的全国代表性样本。使用单变量和多变量逻辑回归分析调整了社会人口经济学因素（性别、年龄、家庭收入、保险状况、健康状况和居住地区）和主要 LCs（高血压、糖尿病、类风湿关节炎、骨质疏松症、脑梗死、心绞痛、心肌梗死、勃起功能障碍、脂蛋白紊乱和肥胖症），以确定 PD 与主要 LCs 之间的关联。患有 PD 的老年参与者发生主要 LCs 的风险更高（高血压：比值比（OR）=1.40，糖尿病：OR=1.22，类风湿关节炎：OR=1.16，骨质疏松症：OR=1.37，勃起功能障碍：OR=1.73，脂蛋白紊乱：OR=1.50，肥胖症：OR=1.59）。我们的纵向队列研究提供了证据，表明 PD 与老年参与者的主要 LCs 显著相关。特别是，PD 与勃起功能障碍之间的关联在多变量分析中具有最高的 OR。
