a Ramboll Environ , Amherst , MA , USA.
b Houston Methodist Hospital - Texas Medical Center , Houston , TX , USA.
Crit Rev Toxicol. 2017 Aug;47(7):592-602. doi: 10.1080/10408444.2017.1301878. Epub 2017 May 2.
Several cross-sectional studies of a single population of workers exposed to formaldehyde at one of two factories using or producing formaldehyde-melamine resins in China have concluded that formaldehyde exposure induces damage to hematopoietic cells that originate in the bone marrow. Moreover, the investigators interpret observed differences between groups as evidence that formaldehyde induces myeloid leukemias, although the mechanisms for inducing these diseases are not obvious and recently published scientific findings do not support causation. Our objective was to evaluate hematological parameters and aneuploidy in relation to quantitative exposure measures of formaldehyde. We obtained the study data for the original study (Zhang et al. 2010 ) and performed linear regression analyses. Results showed that differences in white blood cell, granulocyte, platelet, and red blood cell counts are not exposure dependent. Among formaldehyde-exposed workers, no association was observed between individual average formaldehyde exposure estimates and frequency of aneuploidy, suggested by the original study authors to be indicators of myeloid leukemia risk.
几项针对中国两家使用或生产甲醛-三聚氰胺树脂的工厂的同一工人群体的横断面研究得出结论，甲醛暴露会导致起源于骨髓的造血细胞损伤。此外，研究人员将观察到的组间差异解释为甲醛诱导髓系白血病的证据，尽管诱导这些疾病的机制尚不清楚，最近发表的科学发现也不支持因果关系。我们的目的是评估与甲醛定量暴露测量相关的血液学参数和非整倍性。我们获得了原始研究（Zhang 等人，2010）的研究数据，并进行了线性回归分析。结果表明，白细胞、粒细胞、血小板和红细胞计数的差异与暴露无关。在甲醛暴露的工人中，个体平均甲醛暴露估计值与非整倍体频率之间没有关联，这是原研究作者认为是髓系白血病风险指标的。
