犬尿喹啉酸通过作用于士的宁不敏感的甘氨酸受体来拮抗对N-甲基-D-天冬氨酸的反应。
Kynurenic acid antagonises responses to NMDA via an action at the strychnine-insensitive glycine receptor.
作者信息
Birch P J, Grossman C J, Hayes A G
机构信息
Department of Neuropharmacology, Glaxo Group Research, Ware, Herts., U.K.
出版信息
Eur J Pharmacol. 1988 Sep 1;154(1):85-7. doi: 10.1016/0014-2999(88)90367-6.
Kynurenate produces an unsurmountable antagonism of the response to N-methyl-D-aspartate (NMDA) in the baby rat hemisected spinal cord. This effect is completely reversible and prevented by co-superfusion with D-serine or glycine in the presence of strychnine. In the presence of D-serine kynurenate acts as a weak competitive antagonist. The results suggest that one of the actions of kynurenate is to antagonise NMDA responses via an action at the strychnine-insensitive glycine receptor.
犬尿喹啉酸对新生大鼠半横断脊髓中N-甲基-D-天冬氨酸（NMDA）的反应产生不可克服的拮抗作用。这种作用是完全可逆的，并且在存在士的宁的情况下，与D-丝氨酸或甘氨酸共同灌注可阻止这种作用。在存在D-丝氨酸的情况下，犬尿喹啉酸作为一种弱竞争性拮抗剂起作用。结果表明，犬尿喹啉酸的作用之一是通过作用于对士的宁不敏感的甘氨酸受体来拮抗NMDA反应。
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