Rangel Marcus Vinicius Dos Santos, Lopes Karynne Grutter, Qin Xuebin, Borges Juliana Pereira
Laboratory of Physical Activity and Health Promotion, Institute of Physical Education and Sports, University of Rio de Janeiro State, Rio de Janeiro, RJ, Brazil.
Postgraduate Program in Clinical and Experimental Physiopathology, Faculty of Medical Sciences, State University of Rio de Janeiro, Rio de Janeiro, RJ, Brazil.
Front Sports Act Living. 2025 Mar 6;7:1535152. doi: 10.3389/fspor.2025.1535152. eCollection 2025.
Tryptophan (TRP) metabolism through the kynurenine (KYN) pathway is influenced by inflammatory mediators, generating metabolites that regulate immune and inflammatory responses. Exercise has been proposed as a modulator of this pathway, but its role in health benefits and chronic disease management remains unclear.
This systematic review examines exercise-induced adaptations in the KYN pathway and their potential implications for health and disease management. Additionally, we identify key methodological considerations for future research.
A structured search of PubMed/Medline, Web of Science, and Scopus was conducted up to October 2024 to identify clinical trials investigating the effects of exercise training on the KYN pathway.
Of 2,795 articles initially found, 13 clinical trials involving 592 participants met the inclusion criteria. Most studies reported exercise-induced adaptations in the KYN pathway, particularly in cancer survivors. These adaptations appeared to be influenced by exercise intensity and duration. However, several methodological limitations were noted, and no trials included patients with metabolic or cardiovascular diseases.
Here, we show that exercise training modulates the KYN pathway in both healthy and diseased populations, highlighting its potential for disease prevention and management. However, further randomized-controlled trials are needed to clarify its mechanisms and clinical applications, particularly in metabolic and cardiovascular diseases.
https://www.crd.york.ac.uk/PROSPERO/view/CRD42022351481, PROSPERO (CRD42022351481).
色氨酸（TRP）通过犬尿氨酸（KYN）途径的代谢受炎症介质影响，产生调节免疫和炎症反应的代谢产物。运动被认为是该途径的调节因素，但其在健康益处和慢性病管理中的作用仍不明确。
本系统评价研究运动诱导的KYN途径适应性变化及其对健康和疾病管理的潜在影响。此外，我们确定了未来研究的关键方法学考量因素。
截至2024年10月，对PubMed/Medline、科学网和Scopus进行结构化检索，以确定调查运动训练对KYN途径影响的临床试验。
在最初找到的2795篇文章中，13项涉及592名参与者的临床试验符合纳入标准。大多数研究报告了运动诱导的KYN途径适应性变化，尤其是在癌症幸存者中。这些适应性变化似乎受运动强度和持续时间的影响。然而，注意到一些方法学上的局限性，且没有试验纳入代谢或心血管疾病患者。
在此，我们表明运动训练在健康人群和患病群体中均能调节KYN途径，凸显了其在疾病预防和管理方面的潜力。然而，需要进一步的随机对照试验来阐明其机制和临床应用，尤其是在代谢和心血管疾病方面。
https://www.crd.york.ac.uk/PROSPERO/view/CRD42022351481，PROSPERO（CRD42022351481）
