6,7-二硝基喹喔啉-2,3-二酮和6-硝基-7-氰基喹喔啉-2,3-二酮通过作用于士的宁不敏感的甘氨酸受体来拮抗大鼠脊髓对N-甲基-D-天冬氨酸（NMDA）的反应。
6,7-Dinitro-quinoxaline-2,3-dion and 6-nitro,7-cyano-quinoxaline-2,3-dion antagonise responses to NMDA in the rat spinal cord via an action at the strychnine-insensitive glycine receptor.
作者信息
Birch P J, Grossman C J, Hayes A G
机构信息
Department of Neuropharmacology, Glaxo Group Research Ltd., Ware, Hertfordshire, U.K.
出版信息
Eur J Pharmacol. 1988 Oct 26;156(1):177-80. doi: 10.1016/0014-2999(88)90163-x.
6,7-Dinitro-quinoxaline-2,3-dion (DNQX) and 6-nitro,7-cyano-quinoxaline-2,3-dion (CNQX) produce an unsurmountable antagonism of responses to N-methyl-D-aspartate (NMDA) in the baby rat hemisected spinal cord. These effects of DNQX and CNQX can be prevented in a dose-dependent manner by co-superfusion with D-serine or glycine (in the presence of strychnine). The results suggest that the unsurmountable blockade of NMDA responses by DNQX and CNQX reflects an antagonist effect mediated at the allosterically linked strychnine-insensitive glycine receptor.
6,7-二硝基喹喔啉-2,3-二酮（DNQX）和6-硝基-7-氰基喹喔啉-2,3-二酮（CNQX）对新生大鼠半横断脊髓中N-甲基-D-天冬氨酸（NMDA）的反应产生不可克服的拮抗作用。通过与D-丝氨酸或甘氨酸共同灌注（在存在士的宁的情况下），DNQX和CNQX的这些作用可以以剂量依赖的方式被阻止。结果表明，DNQX和CNQX对NMDA反应的不可克服的阻断反映了在变构连接的对士的宁不敏感的甘氨酸受体介导的拮抗作用。
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