Rozimamat Rushangul, Kehrimen Nurmuhammat, Aisa Haji Akber
a Key Laboratory of Plant Resources and Chemistry of Arid Zone, Xinjiang Technical Institute of Physics and Chemistry, Chinese Academy of Sciences , Urumqi , China.
b University of the Chinese Academy of Sciences , Beijing , China.
Nat Prod Res. 2019 Feb;33(3):380-385. doi: 10.1080/14786419.2018.1455039. Epub 2018 Mar 26.
One new compound alatavinol (1), together with five known compounds, kaempferol (2), quercetin (3), laricircsinol (4), secoisolariciresinol (5) and loliolide (6) were isolated from the whole plant of Euphorbia alatavica Boiss. Those compounds were isolated and purified by various column chromatographic methods and their structures were elucidated by spectroscopic (1D, 2D NMR, and HR-MS) chemical analyses. All compounds were isolated for the first time from E. alatavica Boiss, and biochemical pathway of the new compound has been hypothesized. Furthermore, these compounds were evaluated for antioxidant properties based on the DPPH radical scavenging activities. Results showed that IC values of compounds 1, 3, 4, 5 and 6 were 25.69, 1.88, 2.87, 11.55 and 17.81 μg/mL, respectively, as compared to the control ascorbic acid (5.34 μg/mL).
从阿尔泰大戟（Euphorbia alatavica Boiss.）全草中分离出一种新化合物阿拉他维醇（1），以及五种已知化合物山奈酚（2）、槲皮素（3）、落叶松脂醇（4）、开环异落叶松脂醇（5）和黑麦草内酯（6）。通过各种柱色谱方法对这些化合物进行分离和纯化，并通过光谱（一维、二维核磁共振和高分辨质谱）化学分析阐明其结构。所有化合物均首次从阿尔泰大戟中分离得到，并对新化合物的生化途径进行了推测。此外，基于二苯基苦味酰基自由基清除活性对这些化合物的抗氧化性能进行了评估。结果表明，与对照抗坏血酸（5.34μg/mL）相比，化合物1、3、4、5和6的半数抑制浓度（IC）值分别为25.69、1.88、2.87、11.55和17.81μg/mL。
