Department of Psychiatry of the Second Xiangya Hospital, Central South University, Changsha, Hunan 410011, China; Mental Health Institute of the Second Xiangya Hospital, Central South University, Changsha, Hunan, China; National Clinical Research Center on Mental Disorders, Changsha, Hunan, China; National Technology Institute on Mental Disorders, Changsha, Hunan, China; Hunan Key Laboratory of Psychiatry and Mental Health, Changsha, Hunan, China.
Key Laboratory for NeuroInformation of Ministry of Education, School of Life Science and Technology, University of Electronic Science and Technology of China, Chengdu, Sichuan, China.
Psychiatry Res Neuroimaging. 2017 Jun 30;264:60-67. doi: 10.1016/j.pscychresns.2017.04.010. Epub 2017 Apr 24.
Abnormal short-range and long-range functional connectivities (FCs) have been implicated in the neurophysiology of schizophrenia. This study was conducted to examine the potential of short-range and long-range FCs for differentiating the patients from the controls with a family-based case-control design. Twenty-eight first-episode, drug-naive patients with schizophrenia, 28 unaffected siblings of the patients (family-based controls, FBCs), and 40 healthy controls (HCs) underwent resting-state functional magnetic resonance imaging (fMRI) scans. The data were analyzed by short-range and long-range FC analyses, receiver operating characteristic curve (ROC) and support vector machine (SVM). Compared with the FBCs/HCs, the patients exhibit increased short-range positive FC strength (spFCS) and/or long-range positive FC strength (lpFCS) in the default-mode network (DMN) and decreased spFCS and lpFCS in the sensorimotor circuits. Furthermore, a combination of the spFCS values in the right superior parietal lobule and the lpFCS values in the left fusiform gyrus/cerebellum VI can differentiate the patients from the FBCs with high sensitivity and specificity. The findings highlight the importance of the DMN and sensorimotor circuits in the pathogenesis of schizophrenia. Combining with family-based case-control design may be a viable option to limit the confounding effects of environmental risk factors in neuroimaging studies of schizophrenia.
异常的短程和长程功能连接（FC）与精神分裂症的神经生理学有关。本研究采用基于家系的病例对照设计，旨在探讨短程和长程 FC 区分患者与对照的潜力。28 例首发、未用药的精神分裂症患者、28 名患者无患病的兄弟姐妹（基于家系的对照，FBC）和 40 名健康对照（HC）接受了静息态功能磁共振成像（fMRI）扫描。数据分析采用短程和长程 FC 分析、受试者工作特征曲线（ROC）和支持向量机（SVM）。与 FBC/HC 相比，患者的默认模式网络（DMN）中短程正 FC 强度（spFCS）和/或长程正 FC 强度（lpFCS）增加，感觉运动回路中的 spFCS 和 lpFCS 降低。此外，右侧顶叶的 spFCS 值与左侧梭状回/小脑 VI 的 lpFCS 值的组合可以区分患者和 FBC，具有较高的敏感性和特异性。这些发现强调了 DMN 和感觉运动回路在精神分裂症发病机制中的重要性。结合基于家系的病例对照设计可能是限制精神分裂症神经影像学研究中环境风险因素混杂影响的可行选择。
