Samson Margot, Claassen Daniel O
College of Medicine, University of Central Florida, Orlando, FL, USA.
Neurodegener Dis. 2017;17(4-5):155-165. doi: 10.1159/000460818. Epub 2017 May 3.
The cerebellum modulates diverse neuronal networks, regulating motor, cognitive, behavioral, and limbic circuits. Structural and functional changes to the cerebellum that occur with neurodegenerative conditions have not been systematically reviewed.
We synthesize the current understanding of cerebellar somatotopy and function with previously described cerebellar changes in neurodegenerative diseases not associated with primary cerebellar pathology.
A thorough literature review defines the role of the cerebellum in normal function and neurodegeneration, and we additionally provide exemplar cases of cerebellar dysfunction in neurodegenerative disorders.
Comparisons between normal function and neurodegenerative disease states emphasize how normal organization of the cerebellum is altered in neurodegenerative disease states. We illustrate key anatomic structures using novel cerebellar segmentation tools and images.
Altered cerebellum in neurodegeneration can provide important diagnostic and pathologic insights into both predicting disease progression and network dysfunction.
小脑调节多种神经网络，调控运动、认知、行为和边缘系统回路。神经退行性疾病所伴发的小脑结构和功能变化尚未得到系统综述。
我们将小脑躯体定位和功能的当前认识与先前描述的非原发性小脑病变的神经退行性疾病中的小脑变化进行综合。
全面的文献综述明确了小脑在正常功能和神经退行性变中的作用，并且我们还提供了神经退行性疾病中小脑功能障碍的典型病例。
正常功能与神经退行性疾病状态之间的比较强调了在神经退行性疾病状态下小脑的正常组织结构是如何改变的。我们使用新型小脑分割工具和图像展示关键解剖结构。
神经退行性变中发生改变的小脑可为预测疾病进展和网络功能障碍提供重要的诊断和病理学见解。
