Röckelein G, Hecken-Emmel M
Institute of Pathology, University Erlangen-Nuremberg.
Hepatogastroenterology. 1988 Aug;35(4):151-7.
In a retrospective study, 42 out of 44 cases of hepatocellular carcinoma were investigated immunohistochemically for chronic hepatitis B infection. Surface antigen was found in the liver tissue of only 4 of these cases. In 41 of the patients, mildly to moderately active cirrhosis of the liver was found to be underlying the carcinoma. The age distribution and case histories showed that hepatocellular carcinoma often developed from low-complication cirrhosis of long standing and of various etiologies, and must thus be considered a late complication of cirrhosis.
在一项回顾性研究中，对44例肝细胞癌病例中的42例进行了慢性乙型肝炎感染的免疫组化研究。这些病例中仅4例的肝组织发现表面抗原。41例患者中，发现癌的基础是轻度至中度活动性肝硬化。年龄分布和病史表明，肝细胞癌常由长期存在且病因各异的低并发症肝硬化发展而来，因此必须被视为肝硬化的晚期并发症。
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