Johnson P J
Department of Clinical Oncology, Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, NT, Hong Kong.
Eur J Gastroenterol Hepatol. 1996 Sep;8(9):845-9.
Documentation of the wide geographical variation in the incidence of hepatocellular carcinoma has led to the clear identification of several risk factors. These include chronic infection with hepatitis B and/or hepatitis C and exposure to aflotoxin. All these agents may cause hepatocellular carcinoma but how they interact and how they are related to cirrhosis, which underlies most cases, remains an area of active research. Intervention programmes, most notably immunization against hepatitis B, are now under way and a marked decrease in incidence of hepatocellular carcinoma can be anticipated in the early part of the next century.
肝细胞癌发病率存在广泛地理差异的记录，已明确识别出多种风险因素。这些因素包括慢性乙型肝炎和/或丙型肝炎感染以及接触黄曲霉毒素。所有这些因素都可能导致肝细胞癌，但它们如何相互作用以及如何与大多数病例所基于的肝硬化相关，仍是一个活跃的研究领域。干预项目，最显著的是乙肝疫苗接种，目前正在进行，预计在下个世纪初肝细胞癌发病率将显著下降。
