Imrigha Nada Abusalah Almabrouk, Bidin Noriah, Lau Pik Suan, Musa Nurfatin, Zakaria Nurlaily, Krishnan Ganesan
Laser Center, IBNU-SINA Institute for Scientific and Industrial Research, University Teknologi Malaysia, 81310 UTM, Skudai, Johor, Malaysia.
J Biophotonics. 2017 Oct;10(10):1287-1291. doi: 10.1002/jbio.201600295. Epub 2017 May 2.
Q-switched Nd: YAG laser is the most effective laser for tattoo removal. Photobiomodulation (PBM) therapy is an alternative method applied to accelerate the wound healing. This paper investigated the effects of PBM therapy using 808 nm diode laser on tattooed skin after laser tattoo removal. Forty-five rats were selected and tattooed with black ink on their dorsal, and then distributed into three groups. G0 was received non-laser irradiation. G1 was treated by laser tattoo removal using 1064 nm with energy density of 3.4 J/cm without PBM therapy, while G2 was treated daily with PBM therapy using 808 nm diode laser of 5 J/cm after a single session of laser tattoo removal. The effects of tattoo removal and healing progress of the wound were analyzed using histological studies. Findings showed 808 nm laser promotes the healing process through enhancing epithelialization and collagen deposition. Moreover, PBM therapy stimulated immune cells to improve phagocytosis process for removing the tattoo ink fragments effectively. The PBM therapy treated group was capable of improving the healing process and increasing the quality of skin following the laser tattoo removal. It was also found that stimulation of cellular function by PBM therapy increased tattoo clearance efficiency.
调Q开关钕：钇铝石榴石激光是去除纹身最有效的激光。光生物调节（PBM）疗法是一种用于加速伤口愈合的替代方法。本文研究了使用808 nm二极管激光的PBM疗法对激光纹身去除后纹身皮肤的影响。选取45只大鼠，在其背部用黑色墨水纹身，然后分为三组。G0组接受非激光照射。G1组采用能量密度为3.4 J/cm²的1064 nm激光进行纹身去除，不进行PBM疗法，而G2组在单次激光纹身去除后，每天使用能量密度为5 J/cm²的808 nm二极管激光进行PBM疗法。通过组织学研究分析纹身去除效果和伤口愈合进程。结果表明，808 nm激光通过增强上皮形成和胶原蛋白沉积促进愈合过程。此外，PBM疗法刺激免疫细胞，有效改善吞噬过程以去除纹身墨水碎片。PBM疗法治疗组能够改善激光纹身去除后的愈合过程并提高皮肤质量。还发现PBM疗法对细胞功能的刺激提高了纹身清除效率。
