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用于治疗靶向细胞的药物封装纳米颗粒。

Drug Encapsulated Nanoparticles for Treating Targeted Cells.

作者信息

Suk Koh Hann, Gopinath Subash C B

机构信息

School of Bioprocess Engineering, Universiti Malaysia Perlis, 02600 Arau, Perlis. Malaysia.

出版信息

Curr Med Chem. 2017;24(30):3310-3321. doi: 10.2174/0929867324666170502122444.

Abstract

BACKGROUND

Drug encapsulated nanoparticle has the potency to act as an effective antidote for various diseases. It is possible to enhance the bioavailability of drug encapsulated nanoparticle, whereby the yield is significantly higher compared to the standard formulation. The development with drug encapsulated nanoparticle has been improved drastically after demonstrating its capability of showing the enhanced thermophysical properties and stability of the drug. It is also utilized widely in cancer diagnoses, whereby the surface of the nanoparticle can be modified to enable the nanocarriers to reach the targeted location. Thus, the encapsulated nanoparticle can reveal neural stem cell differentiation due to the multifaceted nature and the biophysical cues to control the cell differentiation.

OBJECTIVE

In this overview, different advantages of the drug encapsulated nanoparticle for the downstream applications are narrated with its appealing characteristics.

CONCLUSION

The application of the drug encapsulated nanoparticle is unrestricted as it can be customized to the specific target cell in the living system.

摘要

背景

药物包裹纳米颗粒有潜力作为治疗各种疾病的有效解毒剂。提高药物包裹纳米颗粒的生物利用度是可能的,与标准制剂相比,其产率显著更高。在证明药物包裹纳米颗粒具有增强的热物理性质和稳定性后,其研发取得了巨大进展。它还广泛应用于癌症诊断,通过修饰纳米颗粒表面使纳米载体能够到达目标位置。因此,由于其多方面的性质和控制细胞分化的生物物理线索,包裹纳米颗粒可以揭示神经干细胞分化。

目的

在本综述中,叙述了药物包裹纳米颗粒用于下游应用的不同优势及其吸引人的特性。

结论

药物包裹纳米颗粒的应用不受限制,因为它可以针对活体系统中的特定靶细胞进行定制。

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