Department of Urology, The Seventh Affiliated Hospital, Sun Yat-sen University, Shenzhen, Guangdong, 518107, China.
Department of Urology, The Third Affiliated Hospital, Sun Yat-sen University, Guangzhou, Guangdong, 510630, China.
Curr Top Med Chem. 2019;19(1):57-73. doi: 10.2174/1568026619666190125145836.
Traditional prostate cancer therapy and especially chemotherapy has faced many challenges. Low accumulation levels, rapid clearance or drug resistance at the tumor site have been central to why the effect of chemotherapy drugs has declined. Applications of nanotechnology to biomedicine have enabled the development of nanoparticle therapeutic carriers suited for the delivery of chemotherapeutics in cancer therapy. This review describes the current nature of nanoparticle therapeutic carriers for prostate cancer. It describes typical nanocarriers commonly used for the delivery of chemotherapy or for imaging examination. Targeting strategies and related influencing factors are investigated to find ways of enhancing treatment effects of nanoparticles. The overall purpose of this review is to further understanding and to offer recommendations on the design and development of therapeutic nanoparticles for prostate cancer.
传统的前列腺癌治疗方法，特别是化疗，面临着许多挑战。化疗药物效果下降的主要原因是肿瘤部位的积累水平低、清除速度快或耐药性。纳米技术在生物医学中的应用使适用于癌症治疗中化疗药物传递的纳米颗粒治疗载体得以发展。本文综述了目前用于前列腺癌的纳米颗粒治疗载体。描述了用于化疗药物传递或成像检查的典型纳米载体。研究了靶向策略及相关影响因素，以寻找增强纳米颗粒治疗效果的方法。本文综述的总体目的是进一步了解并为设计和开发用于前列腺癌的治疗性纳米颗粒提供建议。
