Castillo Paula M, Jimenez-Ruiz Aila, Carnerero Jose M, Prado-Gotor Rafael
Physical Chemistry Department. Faculty of Chemistry, University of Seville, C/Prof. García González, s/n, 41012, Sevilla, Spain.
Chemphyschem. 2018 Nov 5;19(21):2810-2828. doi: 10.1002/cphc.201800388. Epub 2018 Aug 30.
To achieve optimal results when employing nanoparticles in biomedical fields, choosing the right type of nanoparticle and determining the correct procedure for drug loading are key factors. Each type of nanoparticle presents a determined set of characteristics that are, in some cases, unique. In general, their surface charge, geometry or hydrophilic character may be limiting factors, depending on what their intended application is. Once synthesized, additional factors, such as their interaction with biological systems and liberation mechanisms into the target cells, also need to be taken into account. Multiple advantages arise from the use of nanoparticles, such as the capability to solubilize hydrophobic compounds and an increased bioavailability. Those advantages justify the extensive and delicate study that should be undertaken in order to use them as drug delivery agents. One of the most important factors for the design of a drug delivery system with nanoparticles is achieving a high drug-to-nanoparticle ratio. In this Minireview, all of these key factors, both physicochemical and biological, are described, and special emphasis is placed on loading methods employed to introduce drugs into nanoparticles.
要在生物医学领域使用纳米颗粒时获得最佳效果，选择合适类型的纳米颗粒并确定正确的载药程序是关键因素。每种类型的纳米颗粒都具有一系列特定的特性，在某些情况下是独一无二的。一般来说，它们的表面电荷、几何形状或亲水性可能是限制因素，这取决于其预期应用。一旦合成，还需要考虑其他因素，例如它们与生物系统的相互作用以及向靶细胞的释放机制。使用纳米颗粒有多个优点，例如能够溶解疏水化合物并提高生物利用度。这些优点证明了为将它们用作药物递送剂而应进行的广泛而细致的研究是合理的。设计纳米颗粒药物递送系统最重要的因素之一是实现高药物与纳米颗粒比例。在这篇微型综述中，描述了所有这些物理化学和生物学关键因素，并特别强调了用于将药物引入纳米颗粒的载药方法。
