Clinical Phenotype of Endothelial Dysfunction in a Lot of Romanian Scleroderma Patients.
作者信息
Groseanu Laura, Berghea Florian, Balanescu Andra, Predeteanu Denisa, Bojinca Violeta, Saulescu Ioana, Constantinescu Cosmin, Opris Daniela, Abobului Mihai, Borangiu Andreea, Negru Maria-Magdalena, Vlad Violeta, Ionescu Ruxandra
机构信息
"Carol Davila" University of Medicine and Pharmacy, Bucharest, Romania.
出版信息
Maedica (Bucur). 2015 Sep;10(4):336-341.
OBJECTIVES
to identify the particularities of the clinical phenotype of endothelial dysfunction in a lot of Romanian patients from a reference center and compare it to data reported by international registries.
MATERIALS AND METHODS
51 patients were included in a cross sectional study. The patients were evaluated for the pattern of disease, main visceral involvement, serum markers of disease.
RESULTS
41.2% patients had history of digital ulcers, 27.45% had pulmonary arterial hypertension; cardiovascular involvement also included: diastolic dysfunction in 31.1% of the patients, global systolic dysfunction in 9.8%, rhythm and conduction disturbances in 19.6%, peripheral vascular disease in 19.6%. Scleroderma renal crisis was identified in 2 patients.
CONCLUSION
Vascular complications are a major cause of morbidity and mortality in systemic sclerosis. Earlier therapeutic intervention demands improved screening and diagnosis in all cases.
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