van Netten J P, Racca R L, Ashwood-Smith M J, Armstrong J, Fletcher C, Goodchild N L
Department of Pathology, Royal Jubilee Hospital, Greater Victoria Hospital Society, British Columbia, Canada.
J Cancer Res Clin Oncol. 1988;114(5):523-4. doi: 10.1007/BF00391505.
Organized tissue fragments obtained by dissociation of a pure mucoid carcinoma of the breast were cultured in vitro. The cellular organization of the fragments appears similar to that observed in vivo, and consist of mucous-filled spherules surrounded by a single layer of tumour cells. Time-lapse video recordings revealed that the cells surrounding these fragments undergo a concerted contraction and relaxation over the time span of several hours. The presence of cytokeratin and oestrogen receptors in the cells suggests an epithelial derivation. Movement of tumour fragments of the type described here could potentially influence the metastatic process of some breast cancers.
通过解离乳腺纯黏液癌获得的有组织的组织碎片进行了体外培养。这些碎片的细胞组织看起来与体内观察到的相似，由被单层肿瘤细胞包围的充满黏液的小球组成。延时视频记录显示，围绕这些碎片的细胞在数小时的时间跨度内经历协同收缩和舒张。细胞中细胞角蛋白和雌激素受体的存在表明其来源于上皮组织。这里描述的这种类型的肿瘤碎片的移动可能会潜在地影响某些乳腺癌的转移过程。
