Young Cho Yoon, Jeong Kim Hye, Won Jang Hye, Hyuk Kim Tae, Ki Chang-Seok, Wook Kim Sun, Hoon Chung Jae
Division of Endocrinology and Metabolism, Department of Medicine, Gyeongsang National University School of Medicine, Jinju, Korea.
Institute of Health Sciences, Gyeongsang National University School of Medicine, Jinju, Korea.
Endocrine. 2017 Jul;57(1):115-124. doi: 10.1007/s12020-017-1307-4. Epub 2017 May 2.
Levothyroxine supplementation is insufficient for the management of one tenth of patients with hypothyroidism. Iodothyronine deiodinases have been suggested to play a role in residual hypothyroid symptoms of these patients by controlling local thyroid hormone homeostasis. Previous research has suggested a relationship between commonly inherited variations in type 2 iodothyronine deiodinase and impaired well-being. We evaluated the prevalence of iodothyronine deiodinase genotypes and their association with psychological well-being in the Korean hypothyroid population.
A prospective observational study. We enrolled 196 hypothyroid subjects (136 chronic autoimmune thyroiditis and 60 thyroid cancer) and assessed baseline well-being using six validated questionnaires. Genotyping was conducted for 19 single nucleotide polymorphisms in type 1, 2, and 3 iodothyronine deiodinase using Sequenom MassARRAY matrix-assisted laser desorption/ionization time-of-flight mass spectrometry in all patients.
Frequencies of iodothyronine deiodinase genotypes and well-being scores were not different in hypothyroid subjects according to their disease types. Minor genotypes of a few iodothyronine deiodinase 1 variants (rs11206244, rs2294512, and rs4926616) were associated with reduced psychological well-being. However, iodothyronine deiodinase 2 and 3 variants had no effect on baseline well-being.
Minor variations in iodothyronine deiodinase 1 were associated with decreased well-being in the Korean hypothyroid population, whereas iodothyronine deiodinase 2 and 3 were not. Due to controversial results among different ethnicities, further studies to clarify the effects of iodothyronine deiodinase polymorphisms on psychological well-being are warranted in hypothyroid individuals.
左甲状腺素补充治疗对十分之一的甲状腺功能减退患者疗效欠佳。有研究表明，碘甲状腺原氨酸脱碘酶通过控制局部甲状腺激素稳态，在这些患者残留的甲状腺功能减退症状中起作用。此前的研究提示，2型碘甲状腺原氨酸脱碘酶常见的遗传变异与幸福感受损之间存在关联。我们评估了韩国甲状腺功能减退人群中碘甲状腺原氨酸脱碘酶基因型的患病率及其与心理健康的关系。
一项前瞻性观察性研究。我们纳入了196例甲状腺功能减退患者（136例慢性自身免疫性甲状腺炎患者和60例甲状腺癌患者），并使用6份经过验证的问卷评估基线心理健康状况。对所有患者使用Sequenom MassARRAY基质辅助激光解吸/电离飞行时间质谱法，对1型、2型和3型碘甲状腺原氨酸脱碘酶的19个单核苷酸多态性进行基因分型。
根据疾病类型，甲状腺功能减退患者中碘甲状腺原氨酸脱碘酶基因型的频率和幸福感得分并无差异。少数碘甲状腺原氨酸脱碘酶1变异体（rs11206244、rs2294512和rs4926616）的次要基因型与心理健康状况下降有关。然而，碘甲状腺原氨酸脱碘酶2和3变异体对基线心理健康状况没有影响。
在韩国甲状腺功能减退人群中，碘甲状腺原氨酸脱碘酶1的微小变异与幸福感下降有关，而碘甲状腺原氨酸脱碘酶2和3则不然。由于不同种族之间的结果存在争议，有必要进一步研究以阐明碘甲状腺原氨酸脱碘酶多态性对甲状腺功能减退个体心理健康的影响。
