Mount Sinai Medical Center, Department of Surgery, 4300 Alton Road, Miami Beach, FL, 33140, USA.
Mount Sinai Hospital, E 101st St, New York, NY, 10029, USA.
Breast Cancer. 2018 Jan;25(1):28-33. doi: 10.1007/s12282-017-0780-1. Epub 2017 May 2.
Adenoid cystic carcinoma (ACC) of the breast is a rare type of breast cancer, which presents inconsistencies in the optimal management strategy.
A retrospective review of prospectively collected data, spanning the last 20 years, was performed using the cancer registry database at our institution.
Six patients were diagnosed with ACC of the breast, out of 5,813 total patients diagnosed with breast cancer (0.1%). Our identified patients had a median age of 66, all with the early stage cancer (Stage I/II). The average size of the breast lesion was 1.62 cm, and nodal status was negative for all cases. All patients had resection as primary therapy (partial or total mastectomy), with one patient also undergoing external beam radiation and tamoxifen hormonal therapy. Median follow-up was 85 months, with all patients being disease-free at last follow-up.
ACC of the breast has an indolent course, despite triple negative status. Our study suggests that radiation may not be warranted and confirms the rarity of axillary node metastases, indicating that sentinel node excision may also not be necessary. Ultimately, the hope is that our findings along with the reviewed literature will aid in determining the most appropriate options for management of ACC of the breast.
乳腺腺样囊性癌（ACC）是一种罕见的乳腺癌类型，其最佳治疗策略存在不一致性。
对我院癌症登记数据库中过去 20 年的前瞻性收集数据进行回顾性分析。
在 5813 例乳腺癌患者中，有 6 例被诊断为乳腺 ACC（0.1%）。我们发现的患者中位年龄为 66 岁，均为早期癌症（I/II 期）。乳腺病变的平均大小为 1.62cm，所有病例的淋巴结状态均为阴性。所有患者均接受了以手术为主的治疗（部分或全乳切除术），1 例患者还接受了外照射和他莫昔芬激素治疗。中位随访时间为 85 个月，所有患者在最后一次随访时均无疾病。
尽管是三阴性肿瘤，乳腺 ACC 的病程呈惰性。我们的研究表明，放疗可能不是必需的，并证实了腋窝淋巴结转移的罕见性，这表明前哨淋巴结切除也可能不是必要的。最终，我们希望我们的研究结果和已审查的文献将有助于确定乳腺 ACC 最适当的治疗方案。
