Sumpio B E, Jennings T A, Merino M J, Sullivan P D
Ann Surg. 1987 Mar;205(3):295-301. doi: 10.1097/00000658-198703000-00013.
The case records of the Connecticut Tumor Registry were reviewed from 1952-1982. There were 37 cases of adenoid cystic carcinoma of the breast (ACC) from a total of 40,350 invasive breast tumors. Patient survival, complications, and pathologic sections were reviewed. Only 14 of 27 surgical pathology slides available for review could be confirmed histologically as ACC. All patients were white females with a mean age of 64 years. The tumor remained localized to the breast in all cases. Nine patients had either radical or modified radical mastectomy, four patients had either simple mastectomy or lumpectomy, and one patient refused treatment. There was no evidence of axillary node involvement, metastases, or local recurrence after excision. At the time of follow-up, nine patients were alive and disease free and four died of disease unrelated to their breast cancer. The one patient who died of breast cancer had a radical mastectomy and survived 11.7 years after diagnosis. It is concluded that ACC has a favorable biologic behavior characterized by a prolonged clinical course and good prognosis. Simple mastectomy is all that is required as initial treatment, and a chest x-ray and thorough physical examination looking for local recurrence is all that is needed for follow-up.
对康涅狄格肿瘤登记处1952年至1982年的病例记录进行了回顾。在总共40350例浸润性乳腺癌中，有37例乳腺腺样囊性癌（ACC）。对患者的生存情况、并发症和病理切片进行了回顾。在可供复查的27张手术病理切片中，只有14张经组织学证实为ACC。所有患者均为白人女性，平均年龄64岁。所有病例中肿瘤均局限于乳腺。9例患者接受了根治性或改良根治性乳房切除术，4例患者接受了单纯乳房切除术或肿块切除术，1例患者拒绝治疗。切除术后没有腋窝淋巴结受累、转移或局部复发的证据。在随访时，9例患者存活且无疾病，4例死于与乳腺癌无关的疾病。死于乳腺癌的1例患者接受了根治性乳房切除术，诊断后存活了11.7年。结论是，ACC具有良好的生物学行为，其特点是临床病程延长且预后良好。初始治疗只需单纯乳房切除术，随访只需胸部X光检查和全面体格检查以寻找局部复发。
