Yuan Yuan, Zhang Yugen
Institute of Bioengineering and Nanotechnology, 31 Biopolis Way, The Nanos, Singapore, 138669, Singapore.
ChemMedChem. 2017 Jun 7;12(11):835-840. doi: 10.1002/cmdc.201700167. Epub 2017 May 16.
A series of imidazolium oligomers with novel planar and stereo core structures were designed and synthesized. These compounds have symmetric structures with different cores, tails, and linkers. These new imidazolium oligomers demonstrated a desirable set of bioactivities against four types of clinically relevant microbes including E. coli, S. aureus, P. aeruginosa, and C. albicans. The planar oligomers with three di-imidazolium arms and n-octyl tails showed good antimicrobial activity and biocompatibility. Oligomers with ortho-xylylene linkers exhibited higher antimicrobial activity and higher hemolytic ability than those oligomers with para-xylylene linkers. These results shed light on the structure-property relationships of synthetic polymeric antimicrobial agents.
设计并合成了一系列具有新型平面和立体核心结构的咪唑鎓低聚物。这些化合物具有不同核心、尾部和连接基的对称结构。这些新型咪唑鎓低聚物对包括大肠杆菌、金黄色葡萄球菌、铜绿假单胞菌和白色念珠菌在内的四种临床相关微生物表现出理想的生物活性。具有三个二咪唑鎓臂和正辛基尾部的平面低聚物显示出良好的抗菌活性和生物相容性。与具有对二甲苯连接基的低聚物相比，具有邻二甲苯连接基的低聚物表现出更高的抗菌活性和更高的溶血能力。这些结果揭示了合成聚合物抗菌剂的结构-性能关系。
