体力活动、肥胖与弥漫大 B 细胞淋巴瘤和滤泡性淋巴瘤患者的生存
Physical activity, obesity and survival in diffuse large B-cell and follicular lymphoma cases.
机构信息
School of Public Health, Curtin University, Perth, WA, Australia.
Cancer Control Research, British Columbia Cancer Agency, Vancouver, BC, Canada.
出版信息
Br J Haematol. 2017 Aug;178(3):442-447. doi: 10.1111/bjh.14702. Epub 2017 May 3.
There is limited information concerning the impact of physical activity and obesity on non-Hodgkin lymphoma (NHL) prognosis. We examined the associations between pre-diagnosis physical activity and body mass index (BMI) with survival in 238 diffuse large B-cell (DLBCL) and 175 follicular lymphoma cases, with follow-up from 2000 to 2015. The most physically active DLBCL cases had 41% lower risk of dying in the follow-up period than the least active [Hazard ratio (HR) = 0·59, 95% confidence interval (CI) = 0·36-0·96], while obese follicular lymphoma cases had a 2·5-fold risk of dying (HR = 2·52, 95% CI = 1·27-5·00) compared with cases with normal BMI. NHL-specific survival results were similar.
关于身体活动和肥胖对非霍奇金淋巴瘤（NHL）预后的影响，相关信息有限。我们研究了 238 例弥漫性大 B 细胞淋巴瘤（DLBCL）和 175 例滤泡性淋巴瘤病例在诊断前的身体活动和体重指数（BMI）与生存之间的关系，这些病例的随访时间从 2000 年到 2015 年。与最不活跃的病例相比，最活跃的 DLBCL 病例在随访期间死亡的风险降低了 41%（风险比[HR] = 0.59，95%置信区间[CI] = 0.36-0.96），而肥胖的滤泡性淋巴瘤病例的死亡风险是正常 BMI 病例的 2.5 倍（HR = 2.52，95%CI = 1.27-5.00）。NHL 特异性生存结果相似。
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