Department of Psychiatry, University of North Carolina, Chapel Hill, NC, USA.
Department of Neurosurgery, University of North Carolina, Chapel Hill, NC, USA.
Eur Eat Disord Rev. 2017 Sep;25(5):317-328. doi: 10.1002/erv.2517. Epub 2017 May 3.
Psychological and pharmacological interventions for binge-eating disorder have previously demonstrated efficacy (compared with placebo or waitlist control); thus, we aimed to expand that literature with a review of comparative effectiveness. We searched MEDLINE,® EMBASE,® Cochrane Library, Academic OneFile, CINAHL® for binge-eating disorder treatment articles and selected studies using predetermined inclusion and exclusion criteria. Data were sufficient for network meta-analysis comparing two pharmacological interventions; psychological interventions were analysed qualitatively. In all, 28 treatment comparisons were included in this review: one pharmacological comparison (second-generation antidepressants versus lisdexamfetamine) and 26 psychological comparisons. Only three statistically significant differences emerged: lisdexamfetamine was better at increasing binge abstinence than second-generation antidepressants; therapist-led cognitive behavioural therapy was better at reducing binge-eating frequency than behavioural weight loss, but behavioural weight loss was better at reducing weight. The majority of other treatment comparisons revealed few significant differences between groups. Thus, patients and clinicians can choose from several effective treatment options. Copyright © 2017 John Wiley & Sons, Ltd and Eating Disorders Association.
心理和药理学干预暴食症以前已被证明有效（与安慰剂或候补对照组相比）；因此，我们旨在通过对比较有效性的回顾来扩展该文献。我们在 MEDLINE、® EMBASE、® Cochrane Library、Academic OneFile、CINAHL®中搜索了暴食症治疗文章，并使用预定的纳入和排除标准选择了研究。有足够的数据进行比较两种药理学干预的网络荟萃分析；心理干预进行了定性分析。在本综述中，共纳入了 28 项治疗比较：一项药理学比较（第二代抗抑郁药与 lisdexamfetamine）和 26 项心理比较。仅出现了三个具有统计学意义的差异：lisdexamfetamine 在增加断食方面比第二代抗抑郁药更有效；由治疗师主导的认知行为疗法在减少暴食频率方面优于行为减肥，但行为减肥在减轻体重方面更有效。大多数其他治疗比较显示两组之间几乎没有显著差异。因此，患者和临床医生可以从几种有效的治疗选择中进行选择。版权所有 © 2017 约翰威立父子公司和饮食失调协会。
