Avcı Tevfik, Yabanoğlu Hakan, Arer İlker Murat, Koçer Nazım Emrah, Çalışkan Kenan, Börcek Pelin, Ekici Yahya
Department of General Surgery, Başkent University Faculty of Medicine, Ankara-Turkey.
Ulus Travma Acil Cerrahi Derg. 2017 Mar;23(2):128-133. doi: 10.5505/tjtes.2016.02359.
The aim of this study was to investigate clinical manifestation, diagnosis, treatment, and prognosis of patients with primary gastrointestinal non-Hodgkin lymphoma (PGI NHL), whose initial presentation was bowel obstruction or perforation.
Data of patients who underwent surgical intervention due to radiological evidence of perforation or intestinal obstruction and were subsequently diagnosed with intestinal lymphoma at Baskent University hospitals between January 2007 and November 2014 were examined retrospectively. Medical records, clinical history, symptoms, pathological reports, and treatment modalities were analyzed.
Study population comprised 17 patients (8 male, 9 female) with PGI NHL and mean age of 52±20.2 years. Symptoms reported by the patients were abdominal pain, nausea, vomiting, weight loss, and loss of appetite. All 17 patients underwent surgical treatment; 12 also received postoperative chemotherapy. Most common pathological subtype was diffuse large B-cell lymphoma (70.5%). Mean follow-up time was 26 months (range: 1-69 months) and 5-year survival rate was 64.3%.
Initial presentation of PGI NHL may be obstruction with or without perforation; clinicians and surgeons should keep this in mind while assessing patient with bowel obstruction, and particularly patient in fifth decade of life.
本研究旨在调查以肠梗阻或肠穿孔为首发表现的原发性胃肠道非霍奇金淋巴瘤（PGI NHL）患者的临床表现、诊断、治疗及预后。
回顾性分析2007年1月至2014年11月期间在巴斯肯特大学医院因影像学证据显示穿孔或肠梗阻而接受手术干预，随后被诊断为肠道淋巴瘤的患者资料。分析病历、临床病史、症状、病理报告及治疗方式。
研究人群包括17例PGI NHL患者（8例男性，9例女性），平均年龄52±20.2岁。患者报告的症状有腹痛、恶心、呕吐、体重减轻及食欲不振。所有17例患者均接受了手术治疗；12例还接受了术后化疗。最常见的病理亚型是弥漫性大B细胞淋巴瘤（70.5%）。平均随访时间为26个月（范围：1 - 69个月），5年生存率为64.3%。
PGI NHL的首发表现可能是伴有或不伴有穿孔的梗阻；临床医生和外科医生在评估肠梗阻患者，尤其是50岁左右的患者时应牢记这一点。
