Guangdong Provincial Key Laboratory of Malignant Tumor Epigenetics and Gene Regulation, Department of Cardiology, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, Guangzhou, China.
Guangdong Province Key Laboratory of Arrhythmia and Electrophysiology, Guangzhou, Guangdong Province, China.
J Cell Physiol. 2018 Apr;233(4):2804-2814. doi: 10.1002/jcp.25985. Epub 2017 Jun 7.
Vascular calcification (VC) is prevalent in aging, and patients with hypertension, chronic kidney disease (CKD), or diabetes. VC is regarded as an active and complex process that involves multiple mechanisms responsible for calcium deposition in vessel wall. In light of the complicated pathogenesis of VC, effective therapy for ameliorating VC is limited. Thus, it is urgent to explore the potential mechanisms and find new targets for the therapy of VC. Platelet-derived growth factor (PDGF), a potent mitogen, and chemoattractant have been found to disturb the vascular homeostasis by inducing inflammation, oxidative stress, and phenotype transition, all of which accelerate the process of VC. The aim of current review is to present a review about the roles of PDGF in affecting VC and to establish a potential target for treating VC.
血管钙化（VC）在衰老中很常见，并且在高血压、慢性肾脏病（CKD）或糖尿病患者中也很常见。VC 被认为是一种活跃且复杂的过程，涉及多个负责钙在血管壁中沉积的机制。鉴于 VC 的复杂发病机制，改善 VC 的有效治疗方法有限。因此，迫切需要探索 VC 治疗的潜在机制和新靶点。血小板衍生生长因子（PDGF）是一种有效的有丝分裂原和趋化因子，通过诱导炎症、氧化应激和表型转化来扰乱血管内稳态，所有这些都加速了 VC 的进程。本综述的目的是介绍 PDGF 在影响 VC 中的作用，并为治疗 VC 建立一个潜在的靶点。
