Asadi Milad, Zarredar Habib, Zafari Venus, Soleimani Zahra, Saeedi Hossein, Caner Ayse, Shanehbandi Dariush
Department of Basic Oncology, Health Institute of Ege University, Izmir, Turkey.
Tuberculosis and Lung Disease Research Center, Tabriz University of Medical Sciences, Tabriz, Iran.
Cell Biochem Biophys. 2024 Mar;82(1):107-118. doi: 10.1007/s12013-023-01192-7. Epub 2023 Oct 23.
A tumor represents a highly intricate tissue entity, characterized by an exceptionally complex microenvironment that starkly contrasts with the typical physiological surroundings of healthy tissues. Within this tumor microenvironment (TME), every component and factor assume paramount importance in the progression of malignancy and exerts a pivotal influence on a patient's clinical outcome. One of the remarkable aspects of the TME is its remarkable heterogeneity, not only across different types of cancers but even within the same histological category of tumors. In-depth research has illuminated the intricate interplay between specific immune cells and molecules and the dynamic characteristics of the TME. Recent investigations have yielded compelling evidence that several mutations harbored by tumor cells possess the capacity to instigate substantial alterations in the TME. These mutations, often acting as drivers of tumorigenesis, can orchestrate a cascade of events that remodel the TME, thereby influencing crucial aspects of cancer behavior, including its invasiveness, immune evasion, and response to therapies. It is within this nuanced context that the present study endeavors to provide a concise yet comprehensive summary of how specific mutations, within the genetic landscape of cancer cells, can instigate profound changes in TME features. By elucidating the intricate relationship between genetic mutations and the TME, this research aims to contribute to a deeper understanding of cancer biology. Ultimately, the knowledge gained from this study holds the potential to inform the development of more targeted and effective treatments, thereby offering new hope to patients grappling with the complexities of cancer.
肿瘤是一种高度复杂的组织实体，其特征在于异常复杂的微环境，这与健康组织的典型生理环境形成鲜明对比。在这个肿瘤微环境（TME）中，每个组成部分和因素在恶性肿瘤的进展中都至关重要，并对患者的临床结果产生关键影响。TME的一个显著特点是其显著的异质性，不仅在不同类型的癌症之间存在，甚至在同一组织学类型的肿瘤内部也存在。深入研究揭示了特定免疫细胞和分子之间的复杂相互作用以及TME的动态特征。最近的研究提供了令人信服的证据，表明肿瘤细胞携带的几种突变能够引发TME的实质性改变。这些突变通常作为肿瘤发生的驱动因素，可以引发一系列重塑TME的事件，从而影响癌症行为的关键方面，包括其侵袭性、免疫逃避和对治疗的反应。正是在这种微妙的背景下，本研究致力于简要而全面地总结癌细胞基因图谱中的特定突变如何引发TME特征的深刻变化。通过阐明基因突变与TME之间的复杂关系，本研究旨在促进对癌症生物学的更深入理解。最终，从这项研究中获得的知识有可能为开发更有针对性和有效的治疗方法提供信息，从而为应对癌症复杂性的患者带来新的希望。
